Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence

Granata, Lauren; Gildawie, Kelsea R.; Ismail, Nafissa; Brenhouse, Heather C.; Kopec, Ashley M.

doi:10.1016/j.dcn.2022.101143

Cited by 9 publications

(5 citation statements)

References 297 publications

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“…The male-specific developmental processes comprise cell and axon growth, synaptic assembly and activity, and energy metabolism; the female-specific processes involve cell polarity and differentiation, transcriptional repression, steroid hormones, and immune signaling (Friedrich et al, 2022 ). Additionally, the immune system partakes in the sex-specific regulation of neurological functions, such as the regulation of the hypothalamic–pituitary–gonadal axis development across the sexes during puberty (Granata et al, 2022 ). In recent years, one study reported sex differences as a prominent feature of neurodevelopmental disorders.…”

Section: Discussionmentioning

confidence: 99%

“…This may be related to the fact that immune-neural interactions have different mechanisms of action at different stages of puberty. There is no sex difference in HPA axis reactivity before puberty, but there are species-specific age and sex differences in HPA axis stress reactivity and responsiveness during puberty and mid-adolescence, and post-pubertal adolescence has been shown to be a unique period of HPA axis activity (Granata et al, 2022 ). Future studies could explore the differences in immune-neural interactions, and underlying mechanisms, in children and adolescents at different pubertal stages.…”

Section: Discussionmentioning

confidence: 99%

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Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents

Huang,

Zhang,

Sun

et al. 2024

Front. Psychol.

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BackgroundEvidence of the association of certain neurodevelopmental disorder with specific type 2 inflammatory (T2) disease has been found. However, the association of various neurodevelopmental disorders with T2 diseases as a whole remains unclear in low-birth-weight (LBW) infants.ObjectiveTo evaluate the association of type 2 inflammatory (T2) diseases with intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and learning disability (LD) in LBW children and adolescents.MethodsThe study sample was derived from 2005 to 2018 National Health Interview Survey sample child files. LBW children and adolescents aged 3–17 were included. History of T2 diseases (including asthma and atopic dermatitis) and four neurodevelopmental disorders were reported by adults in families. The relationship between T2 diseases and the risk of four neurodevelopmental disorders was investigated through multiple-weighted logistic regression. Age, sex, race/ethnicity, region, highest education in family and ratio of family income to the poverty threshold were adjusted as covariates for model estimation. Subgroup analyses were conducted by age stratification (3–11 and 12–17 years), sex (male and female), and race (white and non-white).Results11,260 LBW children aged 3–17 years [mean age (SE), 9.73 (0.05) years] were included, in which 3,191 children had T2 diseases. History of T2 diseases was associated with an increased risk of neurodevelopmental disorders, with an OR of 1.35 (95% CI, 0.99–1.84) for ID, 1.47 (95% CI, 1.05–2.05) for ASD, 1.81 (95% CI, 1.51–2.16) for ADHD, and 1.74 (95% CI, 1.49–2.04) for LD following the adjustment of all the covariates. The correlations between T2 disorders and each of the four neurodevelopmental disorders were significantly different by sex and race (all P for interaction < 0.001), and no differences were found in age stratification (all P for interaction > 0.05).ConclusionIn a nationally representative sample of children, we found a significant association of T2 diseases with ASD, ADHD, and LD, even after adjusting for demographic baseline. We also found that the association of T2 disease with neurodevelopmental disorders differed between sex and race. Further investigation is needed to evaluate causal relationships and elucidate their potential mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents

Huang,

Zhang,

Sun

et al. 2024

Front. Psychol.

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“…Adolescent MDD is caused by an interaction between genetic and environmental factors. For instance, sex hormones affect the brain by activating the development of the prefrontal cortex, amygdala, and hypothalamus, and hormone and induce physical changes, which may be associated with the increased risk of adolescent MDD ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

Prospective study on Maresin-1 and cytokine levels in medication-naïve adolescents with first-episode major depressive disorder

Qiu

Chen

et al. 2023

Front. Psychiatry

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BackgroundInflammation and immune activation may play a role in the pathological mechanism of Major Depressive Disorder (MDD). Evidence from cross-sectional and longitudinal studies of adolescents and adults has shown that MDD is associated with increased plasma pro-inflammatory cytokines (e.g., IL-1β, IL-6). It has been reported that Specialized Pro-resolving Mediators (SPMs) mediate inflammation resolution, and Maresin-1 can activate the process of inflammation and promote inflammation resolution by promoting macrophage phagocytosis. However, no clinical studies have been conducted to evaluate the relationship between the levels of Maresin-1 and cytokine and the severity of MDD symptomatology in adolescents.Methods40 untreated adolescent patients with primary and moderate to severe MDD and 30 healthy participants as the healthy control (HC) group aged between 13 and 18 years old were enrolled. They received clinical and Hamilton Depression Rating Scale (HDRS-17) evaluation and then, blood samples were collected. Patients in the MDD group were re-evaluated for HDRS-17, and blood samples were taken after a six to eight-week fluoxetine treatment.ResultsThe adolescent patients with MDD had lower serum levels of Maresin-1 and higher serum levels of interleukin 6 (IL-6) compared with the HC group. Fluoxetine treatment alleviated depressive symptoms in MDD adolescent patients, which was reflected by higher serum levels of Maresin-1 and IL-4 and lower HDRS-17 scores, serum levels of IL-6, and IL-1β. Moreover, the serum level of Maresin-1 was negatively correlated with the depression severity scores on the HDRS-17.ConclusionAdolescent patients with primary MDD had lower levels of Maresin-1 and higher levels of IL-6 compared with the HC group, implying that the peripheral level of pro-inflammatory cytokines may be elevated in MDD, resulting in the insufficiency of inflammation resolution. The Maresin-1 and IL-4 levels increased after anti-depressant treatment, whereas IL-6 and IL-1β levels decreased significantly. Moreover, Maresin-1 level negatively correlated with depression severity, suggesting that reduced levels of Maresin-1 promoted the progression of MDD.

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“…Older female functions slower in acute reaction or sickness yet shows resistance to certain long-term infections ( 141 ). Older men, on the other hand, exhibited higher levels of activity in the innate immune system, the body's generic but faster-reacting defense force ( 145 ).…”

Section: Age and Sex Brought Heterogeneousness To Diverse Fibrotic Re...mentioning

confidence: 99%

An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed

Hua,

Gao,

et al. 2023

Front. Cardiovasc. Med.

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Vascular fibrosis is a widespread pathologic condition that arises during vascular remodeling in cardiovascular dysfunctions. According to previous studies, vascular fibrosis is characterized by endothelial matrix deposition and vascular wall thickening. The RAAS and TGF-β/Smad signaling pathways have been frequently highlighted. It is, however, far from explicit in terms of understanding the cause and progression of vascular fibrosis. In this review, we collected and categorized a large number of molecules which influence the fibrosing process, in order to acquire a better understanding of vascular fibrosis, particularly of pathologic dysfunction. Furthermore, several mediators that prevent vascular fibrosis are discussed in depth in this review, with the aim that this will contribute to the future prevention and treatment of related conditions.

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Immune signaling as a node of interaction between systems that sex-specifically develop during puberty and adolescence

Cited by 9 publications

References 297 publications

Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents

Association between type 2 inflammatory diseases and neurodevelopmental disorders in low-birth-weight children and adolescents

Prospective study on Maresin-1 and cytokine levels in medication-naïve adolescents with first-episode major depressive disorder

An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed

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