Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Gomez-Cadena, Alejandra; Barreto, Alfonso; Fioretino, Susana; Jandus, Camilla

doi:10.15698/cst2020.07.224

Cited by 18 publications

(19 citation statements)

References 113 publications

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“…Besides that, it also has been proven to interfere in many signal transduction cascades and interfere with key regulatory effectors. Many secondary metabolites in plants such as phenolics, alkaloids, saponins, and terpenes, have a direct ability to attenuate macrophage proinflammatory activity [43], activate tumor antigen presentation, and enhance adaptive and innate immune systems [44]. Herbal products also play a role in cell cycle modulators and regulate invasion and metastasis depending on the dose given and the phytochemicals that are being used as the modulator [45].…”

Section: Potential Herbal Products As Immunomodulatorsmentioning

confidence: 99%

The Potency of Herbal Active Compounds as Immune Modulators for Cancer Therapy

Wanandi

Maghdalena

2023

Indonesian Journal of Cancer

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Cancer was the second leading cause of death globally in 2018. On the other hand, immunotherapy is one of the most promising and effective therapies to fight against cancer. This area of research has highly increased over the last decade. Immunotherapy will modulate and initiate an effective immune response. Hence, the immune system in the body will be more potent in combating cancer. Cancer immunotherapy can utilize herbal products to modulate the immune system with low toxicity. In addition, the usage of herbal products has also proven to decrease the side effects of conventional cancer therapy. Some herbal products have been proven to have biological and pharmacological activity, such as anti-inflammatory, anticancer, and chemopreventive. Indonesia, with its immense biodiversity of herbal products, can use this advantage to develop these sources in the health sector. We showcase some active compounds such as quercetin, andrographolide, curcumin, resveratrol, capsaicin, epigallocatechin-3-gallate, genistein, 6-shogaol, and 6-gingerol. We further highlight the mechanism and signaling pathways that can occur in these active compounds to suppress cancer progression and development. This review discusses the mechanism and potency of herbal products as a modulator in cancer immunotherapy to combat cancer. In summary, this review summarizes herbal products’ active compounds and future promise within the field of immunotherapy.

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Section: Potential Herbal Products As Immunomodulatorsmentioning

confidence: 99%

The Potency of Herbal Active Compounds as Immune Modulators for Cancer Therapy

Wanandi

Maghdalena

2023

Indonesian Journal of Cancer

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“…In addition to the treatments already known for the treatment of cancer, some plants stand out in traditional medicine for their potential antitumor effect. The natural products obtained from plants have been a source of medicines for many years, and more recently, their use in complex mixtures that allow their activity to be enhanced has been proposed [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The antitumor activity of plant-derived extracts and compounds has sometimes been attributed, in a very simple way, to their antioxidant capacity. However, recent omics approaches have revealed multiple biological activities related to cancer control, among which the ability to modulate the immune response and the tumor microenvironment stands out [ 3 , 12 ]. Tumors can escape from the immune response by inhibiting T cell expansion and function, finally leading to immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

Tillandsia usneoides Extract Decreases the Primary Tumor in a Murine Breast Cancer Model but Not in Melanoma

Lasso

Rojas

Arévalo

et al. 2022

Cancers

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The main limits of current antitumor therapies are chemoresistance, relapses, and toxicity that impair patient quality of life. Therefore, the discovery of therapeutic alternatives, such as adjuvants to conventional therapy that modulate the intracellular oxidation state or the immune response, remains a challenge. Owing to traditional medicine, several uses of plants are known, indicating a promising antitumor and immunomodulatory effect. We evaluated the effect of ethanolic extract of T. usneoides in vitro and in vivo in models of 4T1 breast cancer and B16-F10 melanoma. In vitro evaluations with both cell lines showed that the extract has cytotoxic activity and induces apoptotic cell death. However, its effect on ROS production and glucose uptake was opposite. In vivo, only in the 4T1 model, a significant decrease in tumor size was found in animals treated with the extract, accompanied by an increase in dendritic cells and activated CD8+ T cells, and a decrease in myeloid-derived suppressor-like cells (MDSC-LC) and Tregs in the tumor microenvironment. These results suggest that T. usneoides extract antagonistically regulates tumor metabolism of 4T1 vs. B16-F10, impacting the tumor microenvironment and effective antitumor immune response, leading to a reduction in 4T1 tumor size but not on B16-F10.

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“…Understanding tumour biology has facilitated the development of targeted therapies; however, tumours display multidrug resistance (MDR) as a significant clinical burden due to heterogeneity [ 3 – 6 ]. Natural bioactive compounds from various sources (e.g., plants, microbes) have emerged as immunomodulators in diseases, such as diabetes, cardiovascular diseases (CVDs), inflammation, and cancer [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Rise of the natural red pigment ‘prodigiosin’ as an immunomodulator in cancer

et al. 2022

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Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (e.g., tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural products are interesting repository of bioactive molecules, especially those with anticancer activities. Prodigiosin, a red pigment produced by Serratia marcescens, possesses inherent anticancer characteristics, showing interesting antitumour activities in different cancers (e.g., breast, gastric) with low or without harmful effects on normal cells. The present review discusses the potential role of prodigiosin in modulating and reprogramming the metabolism of the various immune cells in the TME, such as T and B lymphocytes, tumour-associated macrophages (TAMs), natural killer (NK) cells, and tumour-associated dendritic cells (TADCs), and myeloid-derived suppressor cells (MDSCs) which in turn might introduce as an immunomodulator in cancer therapy.

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Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Cited by 18 publications

References 113 publications

The Potency of Herbal Active Compounds as Immune Modulators for Cancer Therapy

The Potency of Herbal Active Compounds as Immune Modulators for Cancer Therapy

Tillandsia usneoides Extract Decreases the Primary Tumor in a Murine Breast Cancer Model but Not in Melanoma

Rise of the natural red pigment ‘prodigiosin’ as an immunomodulator in cancer

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