Immune Thrombocytopenia Associated with Mycoplasma pneumoniae Infection

Abstract

Immune thrombocytopenia (ITP) related to Mycoplasma pneumoniae infection is a rare condition and usually associated with a severe clinical course. We here report a case of a young man with a clinical diagnosis of severe ITP secondary to M. pneumoniae infection. The clinical features, therapy and outcome are presented.LEARNING POINTSImmune thrombocytopenia (ITP) related to Mycoplasma pneumoniae infection is a rare condition.ITP secondary to M. pneumoniae infection appears to be associated with a more severe and refractory clinical course.It remains unclear whether specific anti-Mycoplasma antibiotic therapy is associated with a milder clinical course and a better prognosis.

Immune Thrombocytopenic Purpura: A Sequelae of Mycoplasma pneumoniae Infection

“…On the contrary, ITP due to the M. pneumoniae infection belongs in the second group and this pathophysiology is less well understood. Potential mechanisms reported specifically for M. pneumoniae include platelet aggregation due to immune complexes, platelet clearance, and serotonin release [3]. Both Aviner et al and Gouveia et al reported cases and performed a literature report.…”

“…Both Aviner et al and Gouveia et al reported cases and performed a literature report. The former reported seven cases of ITP, while the latter reported 10 cases though there was some overlap [3,4]. Although the exact mechanism of ITP is unknown, some hypotheses are less likely based on the data from the case series performed by Aviner et al…”

“…Both Aviner et al and Gouveia et al reported cases and performed a literature report. The former reported seven cases of ITP, while the latter reported 10 cases though there was some overlap [ 3 , 4 ]. Although the exact mechanism of ITP is unknown, some hypotheses are less likely based on the data from the case series performed by Aviner et al Contrary to classic ITP where antiplatelet antibodies are usually found, the authors included in the case series that did look for antiplatelet antibodies did not find any [ 4 ].…”

Low Arterial Oxygen Partial Pressure Induces Pulmonary Thrombocytopenia in Patients and a Mouse Model

“…The latest discovery strongly indicated that a large number of MKs circulate through the lungs, where they dynamically release platelets, and an animal model showed that the lungs contributed approximately 50% of total platelet production in mice [3]. It is often observed that thrombocytopenia appears in patients with pulmonary diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD) or respiratory failure (RF), which leads to major bleeding events and death [4][5][6][7]. However, whether pathophysiological state of lung affects platelets is unclear from both clinical and basic research information.…”

Low Arterial Oxygen Partial Pressure Induces Pulmonary Thrombocytopenia in Patients and a Mouse Model.

“…The latest discovery strongly indicated that a large number of MKs circulated through the lungs, where they dynamically released platelets, and an animal model showed that the lungs contributed approximately 50% of total platelet production in mice [3]. It is often observed that thrombocytopenia appears in patients with pulmonary diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD) or respiratory failure (RF), which leads to major bleeding events and death [4][5][6][7]. However, whether pathophysiological state of lung affects platelets is unclear from both clinical and basic research information.…”