Immune thrombocytopenia in ulcerative colitis

Casella, Giovanni; Antonelli, Elisabetta; Villanacci, Vincenzo; Salemme, Marianna; Bella, Camillo Di; Baldini, Vittorio; Bassotti, Gabrio

doi:10.1007/s10151-016-1471-1

Cited by 3 publications

(8 citation statements)

References 4 publications

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“…Practitioners encountering those with NCGS and IBD/IBS should search for new associations between not just Gluten-Free Diets (GFD) but all grains. Patients with Crohn's Disease and Ulcerative Colitis, seem to be more affected by gluten than the other inflammatory bowel diseases [9].…”

Section: Discussionmentioning

confidence: 95%

“…NCGS is characterized by intestinal and extraintestinal symptoms due to the ingestion of gluten-containing food in subjects without CD; these symptoms can identically mimic almost all those in CD [8]. Long-term IDA not responsive to iron prescriptions or supplementation should be taken into consideration in the presentation of NCGS and Irritable Bowel Disease (IBD)/IBS [9]. Practitioners encountering those with NCGS and IBD/IBS should search for new associations between not just Gluten-Free Diets (GFD) but all grains.…”

Section: Discussionmentioning

confidence: 99%

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Non-Celiac Gluten Sensitivity and Iron Deficiency Anemia Reversal through Nutrition: A Case Report

Coetzee¹,

Mari²

2017

J Hum Nutr

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Non-Celiac Gluten Sensitivity (NCGS) is becoming more clearly defined and accepted in the medical literature. Indirect evidence suggests that NCGS is more common than Celiac Disease [1], the latter affecting around 1% of the general population [2]. The National Health and Nutrition Examination Survey, found that 49 cases of NCGS were identified in 7,762 patients from 2009-2010 [3]. The University of Maryland, found the criteria for NCGS in 347 of 5,896 patients observed between 2004 and 2010, which represents 6% of the group evaluated [4]. This case reports on the successful treatment of NCGS and IDA in an individual patient, a 56-year-old Italian-American female using nutritional support. The patient continued conventional Irritable Bowel Syndrome (IBS) and Iron Deficiency Anemia (IDA) treatment while beginning functional nutrition therapy guided by laboratory testing from her physician. After three months of a whole-foods diet following a 'Low Glycemic Gluten Free Diet' (LGGFD) model, her symptomology associated with NCGS including constipation, bloating and stomach pain was reversed, she was off acid reflux medication, and follow-up laboratory studies revealed iron markers within normal range.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Non-Celiac Gluten Sensitivity and Iron Deficiency Anemia Reversal through Nutrition: A Case Report

Coetzee¹,

Mari²

2017

J Hum Nutr

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“…12 Immune thrombocytopenia (ITP) is an immune-mediated disorder reported to occur in patients with UC. 13,14 Similarly to UC, the pathophysiology of ITP comprises complex B-and T-cell immune-mediated mechanisms. 15 Platelets in ITP are destroyed in the blood, liver, and spleen.…”

Section: Introductionmentioning

confidence: 99%

“…22 In the literature, co-occurrence of ITP and HES with UC has been reported. 13,14,18,19,23 The clinical presentation, treatment outcome, and prognosis of these cases vary. To date, the exact etiology of the occurrence of such comorbidities remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Resolved Hypereosinophilic Syndrome and Immune Thrombocytopenic Purpura in Ulcerative Colitis Patients Post Colectomy: A Case Series and Literature Review

Subki¹,

Bokhary²,

Alandijani³

et al. 2022

JIR

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Introduction: Hypereosinophilic syndrome (HES) and immune thrombocytopenic purpura (ITP) have been reported to co-occur with ulcerative colitis (UC). However, the exact pathogenic mechanisms of their occurrence remain elusive. In this article, we aim to describe two cases of UC patients who developed refractory HES and ITP and elaborate on their potential pathogenesis. Case Study: We report two middle-aged patients diagnosed with UC. The first patient developed HES that was refractory to conventional medical therapy of idiopathic HES, and the second developed refractory ITP that failed steroid and immunosuppressive therapy. Both conditions improved considerably following colectomy, suggesting they are of a reactive rather than idiopathic nature. Conclusion:In patients with UC and refractory comorbid HES or ITP, the reactive nature of these comorbidities should be taken into consideration, and colectomy, therefore, should be considered if clinically indicated.

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“…At present, scholars believe that genetic factors, immune factors, intestinal mucosa barrier function factors, environmental factors, and microorganism factors might be related to UC [4]. Since UC is considered as an autoimmune disease, immune factors seem to play an important role in UC [5].…”

Section: Introductionmentioning

confidence: 99%

Probiotics combined with aminosalicylic acid affiliates remission of ulcerative colitis: a meta-analysis of randomized controlled trial

et al. 2019

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We conducted a meta-analysis to evaluate the effect of probiotic combined with aminosalicylic on induction remission maintenance treatment of ulcerative colitis. We conducted systematic searches in several Chinses and English databases from inception to June 2018, screening randomized controlled trial about effect of probiotics combined with aminosalicylic acid on ulcerative colitis. The evaluation indicator was the rate of remission. The relative risk (RR) and 95% confidence interval (CI) were calculated. A total of twenty-seven studies with 1942 patients were included. The results indicated that the remission rate was significantly higher in the group using probiotics combined with aminosalicylic acid than that in the group using aminosalicylic acid alone (RR=1.40, 95%CI: 1.27-1.53, =0.000). The subgroup analysis indicated that probiotics combined with aminosalicylic acid can significantly elevate the remission rate in both mild to moderate (RR=1.33, 95%CI: 1.16-1.54, =0.000) and active stage (RR=1.40, 95%CI: 1.27-1.64, =0.000) ulcerative colitis. In different number of bacterium, drug types, treatment period, the combination with probiotics can significantly increase the remission rate ulcerative colitis. The funnel plot shown slight publication bias. Probiotics in conjunction with aminosalicylic can obviously increase the clinical remission rate of activity ulcerative colitis than drug alone. There was no significant difference between combined with mesalazine and salicylazosulfapyridine.

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Immune thrombocytopenia in ulcerative colitis

Cited by 3 publications

References 4 publications

Non-Celiac Gluten Sensitivity and Iron Deficiency Anemia Reversal through Nutrition: A Case Report

Non-Celiac Gluten Sensitivity and Iron Deficiency Anemia Reversal through Nutrition: A Case Report

Resolved Hypereosinophilic Syndrome and Immune Thrombocytopenic Purpura in Ulcerative Colitis Patients Post Colectomy: A Case Series and Literature Review

Probiotics combined with aminosalicylic acid affiliates remission of ulcerative colitis: a meta-analysis of randomized controlled trial

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