Immune Thrombocytopenic Purpura and Helicobacter pylori Infection

Morselli, Monica; Potenza, Leonardo; Luppi, Mario; Torelli, Giuseppe; Emilia, Giovanni

doi:10.1001/archinte.163.1.120-a

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…This rate appeared almost equal to other previous reports. Our eradication rate was 89.4% (17/19), which is almost similar to other investigators [8][9][10][11]. The temporal profile of platelet counts of the 14 responding patients was similar to the literature (Data was not shown) [10].…”

Section: Discussionsupporting

confidence: 90%

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Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>

Takezako¹,

Sekiguchi²,

Tanimura³

et al. 2013

OJBD

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Background and Objectives: Several recent reports have demonstrated a close linkage between idiopathic thrombocytopenic purpura (ITP) and Helicobacter pylori (H. pylori) infection in some patient's populations. However, the pathogenetic mechanisms of H. pylori-induced thrombocytopenia remain obscure. Therefore, we investigated the prevalence of H. pylori infection pylori and performed a comparative analysis of a subset of H. pylori-infected patients (group A) with non-infected patients (group B) using the standard statistical methods. 9 /L; p = 0.018). Lymphocyte counts at the diagnosis of H. pylori infected cases were significant higher than those of non-infected cases (1.58 ± 0.13 × 10 9 /L vs. 0.86 ± 0.20 × 10 9 /L; mean ± standard deviation; p = 0.010). In addition, the mean lymphocyte count after H. pylori eradication was significantly lower than that of before eradication (1.58 ± 0.13 × 10 9 /L vs. 1.02 ± 0.43 × 10 9 /L; p = 0.012). Interpretation and Conclusions: To our knowledge, this is the first report of the relation between H. pylori infected ITP and the lymphocytosis. We suggest that the lymphocytes might play an important role in the pathogenesis of several cases of ITP with H. pylori infection. We conclude that the further investigation is needed to elucidate the mechanism of lymphocytosis in idiopathic thrombocytopenic purpura patients infected with H. pylori.

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Section: Discussionsupporting

confidence: 90%

“…Since the first case report of Grimaz and colleages [7], several investigators have reported the association of Helicobacter pylori (H. pylori) infection with ITP [8][9][10][11]. They demonstrated a successful improvement of ITP after the eradication of H. pylori.…”

Section: Introductionmentioning

confidence: 99%

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>

Takezako¹,

Sekiguchi²,

Tanimura³

et al. 2013

OJBD

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“…Although the studies reported so far are few and have small series of patients, most of the authors found a high prevalence of H. pylori infection in ITP patients. However, because the majority of the studies were conducted in Italy and Japan, in which the prevalence of H. pylori infection in the healthy population is high (> 70% over the age of 50 years) [34,35], the prevalence of H. pylori infection in ITP patients in these countries may not be different from the prevalence in the healthy population. In contrast, Michel et al.…”

Section: Prevalence Of H Pylori Infection In Itp Patientsmentioning

confidence: 99%

Helicobacter pylori Infection and Immune Thrombocytopenic Purpura: an Update

Franchini

Veneri

2004

Helicobacter

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Data are accumulating on the association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP) and the significant increase in platelet count after bacterial eradication. The aim of this review was to consider the studies so far published on H. pylori infection and ITP in order to evaluate a possible correlation between these two conditions. A review of the literature showed that 278 out of the 482 ITP patients investigated (58%) were positive for H. pylori infection and that the bacterium was eradicated in 88% of cases. Eradication therapy was accompanied by a complete or partial platelet response in approximately half the cases. Overall, these data show that H. pylori eradication in patients with ITP is effective in increasing platelet count. However, because the studies so far published are few, are sometimes controversial and involve small series of patients, further studies on larger numbers of patients with longer follow-up are needed to confirm these preliminary findings.

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Helicobacter pylori-associated immune thrombocytopenia

Franchini

Veneri

2006

Platelets

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Idiopatic thrombocytopenic purpura (ITP), a disorder characterized by autoantibody-mediated platelet destruction, may be primary or secondary to various illnesses including lymphoproliferative, autoimmune, or infectious diseases. There are increasing data on the association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura and the significant increase in platelet count after bacterial eradication. The aim of this review is to consider the studies so far published on Helicobacter pylori infection and idiopathic thrombocytopenic purpura in order to evaluate a possible pathogenic correlation between these two conditions. A review of the literature data show that Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura is effective in increasing platelet count in approximately half of the cases. However, since the studies so far published are few, sometimes controversial and involve small series of patients, further controlled studies on larger numbers of patients with longer follow-up are needed to confirm these preliminary findings.

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Immune Thrombocytopenic Purpura and Helicobacter pylori Infection

Cited by 5 publications

References 27 publications

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>

Helicobacter pylori Infection and Immune Thrombocytopenic Purpura: an Update

Helicobacter pylori-associated immune thrombocytopenia

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Immune Thrombocytopenic Purpura and Helicobacter pylori Infection

Cited by 5 publications

References 27 publications

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by &lt;i&gt;Helicobacter pylori&lt;/i&gt;

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by &lt;i&gt;Helicobacter pylori&lt;/i&gt;

Helicobacter pylori Infection and Immune Thrombocytopenic Purpura: an Update

Helicobacter pylori-associated immune thrombocytopenia

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Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>