Immune thrombocytopenic purpura and legionella infection: A case report highlighting the association

Javed, Aneeqa; Alvi, Muhammad Junaid; Sahra, Syeda; DeChavez, Vincent

doi:10.1016/j.idcr.2022.e01439

Cited by 1 publication

(1 citation statement)

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“…The first case was reported in 1982 by Riggs et al [ 122 ]. Recently, Javed et al reported a case of a 61-year-old woman with critical bleeding and severe thrombocytopenia [ 123 ].…”

Section: Bacteriemiamentioning

confidence: 99%

Legionella pneumophila: The Journey from the Environment to the Blood

Iliadi

Staykova

Iliadis

et al. 2022

JCM

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An outbreak of a potentially fatal form of pneumonia in 1976 and in the annual convention of the American Legion was the first time that Legionella spp. was identified. Thereafter, the term Legionnaires’ disease (LD) was established. The infection in humans is transmitted by the inhalation of aerosols that contain the microorganisms that belong to the Legionellaceae family and the genus Legionella. The genus Legionella contains genetically heterogeneous species and serogroups. The Legionella pneumophila serogroup 1 (Lp1) is the most often detected strain in outbreaks of LD. The pathogenesis of LD infection initiates with the attachment of the bacterial cells to the host cells, and subsequent intracellular replication. Following invasion, Legionella spp. activates its virulence mechanisms: generation of specific compartments of Legionella-containing vacuole (LCV), and expression of genes that encode a type IV secretion system (T4SS) for the translocation of proteins. The ability of L. pneumophila to transmigrate across the lung’s epithelium barrier leads to bacteremia, spread, and invasion of many organs with subsequent manifestations, complications, and septic shock. The clinical manifestations of LD depend on the bacterial load in the aerosol, the virulence factors, and the immune status of the patient. The infection has two distinct forms: the non- pneumatic form or Pontiac fever, which is a milder febrile flu-like illness, and LD, a more severe form, which includes pneumonia. In addition, the extrapulmonary involvement of LD can include heart, brain, abdomen, and joints.

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“…The first case was reported in 1982 by Riggs et al [ 122 ]. Recently, Javed et al reported a case of a 61-year-old woman with critical bleeding and severe thrombocytopenia [ 123 ].…”

Section: Bacteriemiamentioning

confidence: 99%