Immune thrombocytopenic purpura secondary to <i>Helicobacter pylori</i>

Ramachandran, Lintu; Baloch, Luqman; Djirdeh, Taha Mohamed; Sidhu, Yadwinder; Gentile, Nicole; Affinati, Mario

doi:10.1080/08998280.2021.1973293

Cited by 2 publications

(2 citation statements)

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“…It is also concerned that either thrombocytopenia severity or disease duration impacts platelet resolution [7]. We have tabulated the cases of ITP that showed full recovery after H. pylori eradication therapy (Table 2) [3,5,[8][9][10][11]. The pathophysiology of ITP induced by H. pylori remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…H. pylori treatment therapy includes PPIs and a combination of amoxicillin, metronidazole, and clarithromycin. The duration of eradication therapy is seven to 14 days, and treatment efficacy is checked after eight-week post therapy through serum platelet count and stool antigen testing [8][9][10]. Our patient presented with hematemesis, petechia, and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

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Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review

Sadia¹,

Abro²,

Ali³

et al. 2022

Cureus

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Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the production of autoantibodies against the platelet surface antigens. ITP is a diagnosis of exclusion and is further categorized into primary and secondary ITP. The etiology of primary ITP is idiopathic, and secondary ITP is caused by infections and autoimmune disorders. Among infectious etiology of ITP, human immunodeficiency virus, herpes virus, and hepatitis B and C virus are common. Helicobacter pylori (H. pylori) is a rare cause of ITP, and the relationship between ITP and H. pylori is highlighted in the literature. We report a case of ITP in an adult female who presented with hematemesis and petechial rash in the lower limbs. Her initial laboratory results demonstrated thrombocytopenia, and the results of her gastric biopsy and stool antigen were positive for H. pylori. She was diagnosed with ITP induced by H. pylori because additional causes of ITP were not identified. Her clinical improvement and platelet recovery after initiating H. pylori eradication therapy were consistent with H. pylori-induced ITP.

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