Immune Thrombocytopenic Purpure and Coeliac Disease

Hammami, S.; Hadded, S.; Lajmi, K.; Besbès, L. Ghédira; Meriem, C. Ben; Chouchane, S.; Guédiche, M.N.

doi:10.1111/j.1440-1754.2011.02052.x

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…Celiac disease and long-standing persistent thrombocytopenia were documented in this patient over more than a decade. In contrast to a previous report [7], thrombocytopenia was chronic and persisted despite successful management of celiac disease with a gluten-free diet. The gluten-free diet appeared to have no effect on the platelet count despite more than a decade of gluten-free diet treatment.…”

Section: Discussioncontrasting

confidence: 99%

Immune Thrombocytopenia in Adult Celiac Disease

Freeman¹

2018

IJCD

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Celiac disease has been associated with a number of immune-mediated hematologic disorders, including idiopathic or immune thrombocytopenic purpura (ITP). Review of the literature suggests that children are particularly affected, often with overt skin findings, but in this report, a 39-yr old male with biopsy-defined celiac disease was detected with a persistent immune-mediated reduction in his platelet count despite treatment and follow-up for more than a decade. Although the celiac disease resolved with a strict gluten-free diet, there was no effect on the ITP. Experience suggests that ITP may be rarely appreciated in adults (compared to children) because it may be limited in severity and occurs without clinically obvious purpura or evidence of bleeding, even with diagnostic or therapeutic biopsy procedures. A subsequent retrospective review of over 300 celiac disease patient records from a single teaching hospital clinical practice experience spanning almost 40 years confirmed no additional cases of thrombocytopenia. ITP appears to be rarely associated with celiac disease in adults and, in spite of resolution of the enteropathy, did not appear to respond to a gluten-free diet, even after more than a decade of dietary treatment.

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Section: Discussioncontrasting

confidence: 99%

Immune Thrombocytopenia in Adult Celiac Disease

Freeman¹

2018

IJCD

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“…The literature described how a gluten-free diet could improve ITP in a year without using corticosteroids or immunoglobulin [13]. After the administration of a gluten-free diet, the platelet count normalized in 5 months in our patient.…”

Section: Discussionmentioning

confidence: 69%

Celiac Disease Presenting with Immune Thrombocytopenic Purpura

Sarbay

Akın

et al. 2017

Case Reports in Hematology

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“…In cases of ITP associated with CD cited in the literature, an increase in platelet count to normal limit within an average of 1 year was observed with gluten-free diet and without the need for intravenous immunoglobulin or steroid treatment [ 19 ]. In our patient, platelet count 1 month after initiation of gluten-free diet was 87,000/mm 3 , and at 5 months, value was normal.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Celiac Disease in Patients Followed by Immun Thrombocytopenic Purpura Diagnosis and Comparison with Literature

Sarbay

Kocamaz

Akın

et al. 2017

North Clin Istanbul

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OBJECTIVE:Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) may occur together as a result of similar autoimmune mechanisms. The aim of this study was to assess the frequency of CD in a group of ITP patients and in the literature.METHODS:A total of 29 patients in Pamukkale University Faculty of Medicine Hospital Pediatric Hematology and Oncology Department with ITP were included in the study. Test was performed for the antibodies related to CD. Positive result for celiac antibodies was confirmed with biopsy. The results were compared with the literature.RESULTS:Of the study group, 13 patients (44.8%) were female and 16 (55.2%) were male. The mean age was 7.2±4.7 years and mean platelet count at the time of admission was 13,440±11,110/mm3 (range: 2000-41,000/mm3). Twelve patients (41.4%) were diagnosed as acute ITP, 6 patients (20.7%) as persistent ITP, and 11 patients (37.9%) as chronic ITP, according to the duration of thrombocytopenia. Antibody positivity was detected in 1 patient. Histological evaluation was compatible with CD. Results were compared with studies regarding the prevalence of CD in the population. No significant difference was found.CONCLUSION:Although it is not necessary to perform CD test in every case of ITP, the presence of differential diagnosis of CD is important to prevent unnecessary treatment, especially in ITP patients with growth retardation or malabsorption findings.

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Immune Thrombocytopenic Purpure and Coeliac Disease

Cited by 10 publications

References 5 publications

Immune Thrombocytopenia in Adult Celiac Disease

Immune Thrombocytopenia in Adult Celiac Disease

Celiac Disease Presenting with Immune Thrombocytopenic Purpura

Investigation of Celiac Disease in Patients Followed by Immun Thrombocytopenic Purpura Diagnosis and Comparison with Literature

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