Immunisation anti-érythrocytaire dans les hémoglobinopathies : à propos de 84 cas

Amor, Imed Ben; Louati, Nour; khemekhem, Hamadi; Dhieb, A; Rekik, H.; Mdhaffar, M.; Gargouri, Jalel

doi:10.1016/j.tracli.2012.06.006

Cited by 16 publications

(7 citation statements)

References 43 publications

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“…This technique is very sensitive, well standardized and allows the detection of all clinically significant antibodies. It has often been used by other authors in the literature [9].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

S Hounogbé,

Magnang,

L Nadjir

et al. 2023

Int J Blood Transfus Immunohematol

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Aims: Red blood cells transfusion exposes recipients to a risk of immunization. The phenotyping of red blood cells and the search for irregular erythrocyte antibodies ensure immuno-hematological safety of the transfused patients. In Togo, these tests are not systematic in transfusion. The aim of the study was to determine the rate of immunization against erythrocyte antigens in polytransfused patients in Lomé. Methods: The search for irregular agglutinins was carried out by the indirect antiglobulin test in gel-filtration in 100 polytransfused patients selected at National Center for Research and Care of Sickle Cells disease and in the care units of Campus Teaching Hospital of Lomé in Togo, from October 1, 2021 to April 30, 2022. Results: The prevalence of alloimmunization was 27% with a total of 13 different alloantibodies identified. The most represented were anti-K (18.52%), anti-E (14.81%), anti-C (11.11%), anti-Jka (11.11%), and anti-M (11.11%). Alloantibodies were more frequent in A+ blood group patients and those who received more than 4 bags of packed red blood cells. There was no link between age, sex, and the pathologies involved on one hand, and the occurrence of anti-erythrocyte alloimmunization on the other. Conclusion: The rate of immunization against erythrocyte antigens is very high in polytransfused patients in Lomé. Systematic implementation of red blood cells phenotyping and irregular erythrocyte antibodies research before and after transfusion should ensure better immunological transfusion safety in Togo.

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“…This technique is very sensitive, well standardized and allows the detection of all clinically significant antibodies. It has often been used by other authors in the literature [9].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

S Hounogbé,

Magnang,

L Nadjir

et al. 2023

Int J Blood Transfus Immunohematol

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“…L'autre principal facteur de risque d'AIFM est un antécédent de transfusion sanguine [8,19]. Nous savons qu'il est très rare que les conséquences d'une allo-immunisation au cours d'une première grossesse aient des répercussions sur ce premier enfant à naître [12,17].…”

Section: Discussionunclassified

“…En effet, en cas de transfusion sanguine maternelle (le plus fréquemment suite à une hémor-ragie du post-partum) il convient d'utiliser des concentrés de globules rouges phénotypés et compatibles [8][9][10][11]. Concernant le foetus et le futur nouveau-né, la principale conséquence de ces AIFM est l'anémie hémolytique.…”

Section: Introductionunclassified

Allo-immunisations fœto-maternelles : dangerosité et absence de prévention des immunisations autres qu’anti-RH1

Ralli¹,

Nadjafizadeh²,

André-Botté³

2015

La Revue Sage-Femme

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“…The immunogenic capacity of the red blood cell antigens varies and the consequences of incompatible antigen transfusion are not similar. The immunogenic antigens are in order of decreasing frequency: the antigens D, E, C and Kell and the most frequent alloantibodies are anti D, anti-E anti-C and anti-K [16,17,18]. In the study, about 77% and 76% of the patients were the phenotype Rh cc and Rh ee respectively.…”

Section: Blood Grouping Phenotype Rhesus and Kellmentioning

confidence: 99%

Incompatible blood transfusion in children in Burkina Faso

Kafando¹,

Nana²,

Domo³

et al. 2016

Open J Hematol

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Immunisation anti-érythrocytaire dans les hémoglobinopathies : à propos de 84 cas

Cited by 16 publications

References 43 publications

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

Allo-immunisations fœto-maternelles : dangerosité et absence de prévention des immunisations autres qu’anti-RH1

Incompatible blood transfusion in children in Burkina Faso

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