Immunité maternelle et transmission mère-enfant du VIH et du VHC

Ransy, Doris G.; Akouamba, Bertine S.; Samson, Johanne; Lapointe, Normand; Soudeyns, Hugo

doi:10.1051/medsci/20072311991

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…This HCV infection route was not investigated. Anti-HCV prevalence among pregnant women and mother-to-child HCV transmission have been discussed in the literature [50–54]. The number of anti-HCV-positive women in our cohort was only 14 and only 10 answered the question about childbirth – 7 (70%) had children – and 171 anti-HCV-negative women, answered a question about childbirth – 54 (32%) had children.…”

Section: Discussionmentioning

confidence: 85%

Anti-HCV prevalence in the general population of Lithuania

Liakina

Valantinas

2012

Med Sci Monit

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SummaryBackgroundThe aim of this study was to assess risk factors for HCV acquisition and prevalence of anti-HCV in the general population of Lithuania.Material/MethodsThe study enrolled 1528 randomly selected adults from the 5 biggest cities of Lithuania and its rural regions. Screening for anti-HCV was performed by analysis of peripheral capillary blood with lateral flow immunochromatography and confirmation of positive cases by peripheral venous blood testing with 2-step chemiluminescent microparticle immunoassay.ResultsAnti-HCV prevalence in Lithuania is 2.78% and according to the standard European population the adjusted anti-HCV rate is 2.85%. It is more prevalent among men (crude rates: 4.02% males vs. 1.49% females, p=.0030) and this does not depend on age. Vilnius and Kaunas regions have higher infection rates than smaller rural regions (2.92% and 3.01% vs. 2.24%, 0.74% and 1.35%). Nowadays among our population HCV infection spreads mainly via intravenous drug use (OR=42.5, p<.0001). HCV transmission occurs through blood transfusions (OR=6.4, p=.0002), tooth removal (OR=4.1, p=.0048), childbirth (OR=5.0, p=.0224), multiple and a long-term hospitalization (OR=3.0, p=.0064), tattooing (OR=4.4, p=.0013), open traumas (OR=3.7, p=.0009) and intrafamilially (OR=11.3, p=.0002).Conclusions2.78% of the population is anti-HCV-positive. The anti-HCV rate is higher in Vilnius and Kaunas in comparison with other regions. HCV spreads mainly through intravenous drug use, but intrafamilial and some nosocomial routes are also important. The anti-HCV prevalence did not depend on age. Despite active prevention of nosocomial HCV transmission, the incidence of HCV infection does not decrease due to virus spread mostly in “trusted networks” of intravenous drug users.

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Section: Discussionmentioning

confidence: 85%

Anti-HCV prevalence in the general population of Lithuania

Liakina

Valantinas

2012

Med Sci Monit

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Transmisión vertical del virus de la inmunodeficiencia humana en la era del tratamiento antirretroviral de gran actividad

Medrano¹,

Soriano²

2009

Medicina Clínica

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HCV prevalence and co‐infection with HIV among pregnant women in Saint Camille Medical Centre, Ouagadougou

Zeba

Karou

Sagna

et al. 2011

Tropical Med Int Health

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Summaryobjective To determine hepatitis C virus (HCV) prevalence and the rate of HCV ⁄ human immunodeficiency virus (HIV) co-infection in pregnant women attending Saint Camille medical centre (SCMC) in Ouagadougou. methodsA total of 607 pregnant women, 16-45 years old, with <32 weeks amenorrhoea were screened for HCV and HIV using rapid tests. The majority of the women included in the study were previously known as HIV infected, as the centre is a reference centre for the programme of prevention against mother-to-child HIV transmission in the country. HCV RNA was extracted and quantified using the cDNA polymerase chain reaction with the nested primers at the 5¢ untranslated region. Transaminases were measured from plasma samples using spectrophotometric method. resultsOf women, 62.27% were infected with HIV. The prevalence of HCV was 2.14% in the screened pregnant women: 1.75% in HIV-negative women and 2.38% in HIV-positive ones. This prevalence is not significantly different between HIV-positive and HIV-negative pregnant women (P = 0.81). HCV RNA was found in all women with anti-HCV. A significant transaminase increase was noted in women infected with HCV (P = 0.01 and P < 0.01 for glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase, respectively). Risk factors significantly associated with HCV positivity in pregnant women included transfusion and genital excision. In addition, the infection was linked with the educational level of the women. conclusionThe issue of this study revealed that effort should be made to promote safe medical practices and fight against women genital excision that are found to be the main risk factors associated with the HCV infection. keywords hepatitis C virus, human immunodeficiency virus, pregnancy, transaminase, Burkina Faso

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Immunité maternelle et transmission mère-enfant du VIH et du VHC

Cited by 4 publications

References 48 publications

Anti-HCV prevalence in the general population of Lithuania

Anti-HCV prevalence in the general population of Lithuania

Transmisión vertical del virus de la inmunodeficiencia humana en la era del tratamiento antirretroviral de gran actividad

HCV prevalence and co‐infection with HIV among pregnant women in Saint Camille Medical Centre, Ouagadougou

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