Immunity for tumors and microbes after autotransplantation: if you build it, they will (not) come

Rapoport, Aaron P.

doi:10.1038/sj.bmt.1705242

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…Some but not all retrospective studies suggest that more rapid lymphocyte recovery during the early post-transplant period may be associated with better clinical outcomes for myeloma and other hematologic neoplasms (9–11). Furthermore, immune dysfunction following high-dose chemotherapy is clearly associated with an increased risk for serious bacterial and viral infections (12–14). Thus, strategies to augment the recovery and function of autologous T cells post-transplant may be beneficial.…”

Section: Introductionmentioning

confidence: 99%

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Rapoport

Stadtmauer

Aqui

et al. 2009

Clinical Cancer Research

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Purpose: Previously, we showed that adoptive transfer of in vivo vaccine-primed and ex vivo (anti-CD3/anti-CD28) costimulated autologous T cells (ex-T) at day +12 after transplant increased CD4 and CD8 T-cell counts at day +42 and augmented vaccine-specific immune responses in patients with myeloma. Here, we investigated the safety and kinetics of T-cell recovery after infusing ex-Tat day +2 after transplant. Experimental Design: In this phase I/II two-arm clinical trial, 50 patients with myeloma received autografts after high-dose melphalan followed by infusions of ex-T at day +2 after transplant. Patients also received pretransplant and posttransplant immunizations using a pneumococcal conjugate vaccine only (arm B; n = 24) or the pneumococcal conjugate vaccine plus an HLA-A2^restricted multipeptide vaccine for HLA-A2 + patients (arm A; n = 26).

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Section: Introductionmentioning

confidence: 99%

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Rapoport

Stadtmauer

Aqui

et al. 2009

Clinical Cancer Research

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Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies

Rapoport

Ijaz

2013

Advances in Tumor Immunology and Immunotherapy

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Immune Deficits in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Mir

Battiwalla

2009

Mycopathologia

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Immune deficits account for the high frequency of life threatening bacterial, viral, and fungal opportunistic infections seen in allogeneic HSCT recipients. Despite advances in infectious disease management, the integrity of host defenses remains the mainstay of defense. The intensity of the preparative regimen, degree of HLA matching, source of stem cells (marrow, blood, or cord), extent of T-cell depletion, and immunosuppressive therapy are some of the factors that impact the kinetics, characteristics, and quality of immune reconstitution. Graft-versus-host disease and its prophylaxis or treatment produce a host environment that is particularly vulnerable to infections. Mucosal disruption and prolonged severe neutropenia usually confine their impact to the early course of transplant. After initial engraftment, HSCT recipients remain at great risk for opportunistic infections and this is related to prolonged and severe T-lymphocyte dysfunction of a complex multifactorial nature. B cell dysfunction is less problematic clinically, but includes deficiencies of immunoglobulin subclasses and impaired ability to mount a vaccine response. Advances in understanding of these immune deficits have resulted in successful strategies including revaccination, growth factors, thymic protection, and adoptive cellular therapy with antigen-specific cells.

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Immunity for tumors and microbes after autotransplantation: if you build it, they will (not) come

Cited by 5 publications

References 56 publications

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies

Immune Deficits in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

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