Encyclopedia of Life Sciences 2017
DOI: 10.1002/9780470015902.a0021982.pub2
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Immunity, Granzymes and Cell Killing

Abstract: Cytotoxic lymphocytes protect us from viral infection and cancer by directly killing tumour cells or cells harbouring a virus. One crucial mechanism they use to kill their targets is known as the ‘granule exocytosis’ pathway. This involves secretion of a potent mix of toxins, resulting in transfer of granule proteases (granzymes) from the killer cell into the target cell, where they cleave various intracellular substrates to activate diverse signalling pathways to cell death. Access to the target cell cytosol … Show more

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