Immunity, immunomodulation, and antibiotic alternatives to maximize the genetic potential of poultry for growth and disease response

Kim, Woo Hyun; Lillehoj, Hyun S.

doi:10.1016/j.anifeedsci.2018.09.016

Cited by 77 publications

(65 citation statements)

References 60 publications

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“…However, this is an important aspect to animal health and some examples are provided elsewhere [31,34,35]. Additionally, there are outstanding reviews available that address the specific role of the GIT with regard to immunomodulation [27,36,37] and therefore, will not be covered herein.…”

Section: Nutritionmentioning

confidence: 99%

Modulation of the Immune Response to Improve Health and Reduce Foodborne Pathogens in Poultry

et al. 2019

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Salmonella and Campylobacter are the two leading causes of bacterial-induced foodborne illness in the US. Food production animals including cattle, swine, and chickens are transmission sources for both pathogens. The number of Salmonella outbreaks attributed to poultry has decreased. However, the same cannot be said for Campylobacter where 50–70% of human cases result from poultry products. The poultry industry selects heavily on performance traits which adversely affects immune competence. Despite increasing demand for poultry, regulations and public outcry resulted in the ban of antibiotic growth promoters, pressuring the industry to find alternatives to manage flock health. One approach is to incorporate a program that naturally enhances/modulates the bird’s immune response. Immunomodulation of the immune system can be achieved using a targeted dietary supplementation and/or feed additive to alter immune function. Science-based modulation of the immune system targets ways to reduce inflammation, boost a weakened response, manage gut health, and provide an alternative approach to prevent disease and control foodborne pathogens when conventional methods are not efficacious or not available. The role of immunomodulation is just one aspect of an integrated, coordinated approach to produce healthy birds that are also safe and wholesome products for consumers.

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Section: Nutritionmentioning

confidence: 99%

Modulation of the Immune Response to Improve Health and Reduce Foodborne Pathogens in Poultry

et al. 2019

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“…[7][8][9] In recent years, novel alternatives have been developed. 10,11 Among them, metal oxide NPs are popular due to their high volume ratio and photocatalytic effect, which endow effective antibacterial properties to the metal oxide NPs. 12 ZnO, CuO, Fe 2 O 3 , and Ag 2 O possess good antibacterial properties, and their bacteriostatic mechanism is different.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and comparison of antibacterial effects and elucidating the mechanism of ZnO, CuO and CuZnO nanoparticles supported on mesoporous silica SBA-3

et al. 2020

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“…Poultry is the world's primary source of animal protein and it represents one of the highest consumers of antibiotics as growth promoters [3]. The European ban on sub-therapeutic use of antibiotics (1831( /2003( /EC, 2006 and the growing awareness among the consumers of the fatalistic effects of antibiotic resistance as well as residues in animal products intensified the hunt for effective in-feed antibiotic surrogates without affecting animal productivity or product quality [4][5][6]. However, the major challenges associated with antibiotic-free poultry production are poor growth performance, lower productivity, and increased morbidity as well as mortality in birds [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…However, the major challenges associated with antibiotic-free poultry production are poor growth performance, lower productivity, and increased morbidity as well as mortality in birds [7,8]. Many reviews shedding light on efficient and cost-effective antibiotic alternatives in poultry have been published in recent times [2,6,[9][10][11]. Recently, plant-derived feed additives have gained considerable interest as sustainable substitutes in poultry diets [12,13].…”

Section: Introductionmentioning

confidence: 99%

The Genus Allium as Poultry Feed Additive: A Review

Kothari

Lee

Niu

et al. 2019

Animals

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The genus Allium, belonging to the family Amaryllidaceae has been known since ancient times for their therapeutic potentials. As the number of multi-drug resistant infections has increased due to in-feed antibiotic usage in poultry, the relevance of alliums as feed additives has been critically assessed. Garlic and the other Allium species, such as onions, leek, shallot, scallion, and chives, have been characterized to contain a plethora of bioactive compounds such as organosulfur compounds, polyphenols, saponins, fructans, and fructo-oligosaccharides. Consequently, alliums have been validated to confer antioxidant, antibacterial, antiviral, immunostimulatory, gut homeostasis, and lipid- as well as cholesterol-lowering properties in poultry. This review intends to summarize recent progress on the use of edible alliums as poultry feed additives, their beneficial effects, and the underlying mechanisms of their involvement in poultry nutrition. Perspectives for future research and limitations are also briefly discussed.

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Immunity, immunomodulation, and antibiotic alternatives to maximize the genetic potential of poultry for growth and disease response

Cited by 77 publications

References 60 publications

Modulation of the Immune Response to Improve Health and Reduce Foodborne Pathogens in Poultry

Modulation of the Immune Response to Improve Health and Reduce Foodborne Pathogens in Poultry

Synthesis, characterization, and comparison of antibacterial effects and elucidating the mechanism of ZnO, CuO and CuZnO nanoparticles supported on mesoporous silica SBA-3

The Genus Allium as Poultry Feed Additive: A Review

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