Immunity in Down's syndrome

Ablin, Richard J.; Seger, Reinhard; Ströder, J

doi:10.1007/bf00445771

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…This suggests that immunodeficiency may be an important component of DS (6). Abnormalities of cell-mediated, humoral, and phagocytic functions have been described in DS (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) but the findings have not been consistent. This inconsistency has been variously attributed to factors such as age variability between subjects and controls, institutionalization as a cause of exposure to frequent infections, and persistence of HBsAg in the blood of DS subjects (6,15,19,20).…”

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confidence: 99%

Age-Related Changes in Humoral and Cell- Mediated Immunity in Down Syndrome Children Living at Home

et al. 1987

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ABSTRACT. Abnormalities of humoral and cell-mediated TC, T cells immunity have been described in Down syndrome but HC, helper cells reported findings have been inconsistent. Confounding fac-SC, suppressor cells tors have included age, institutional versus home life, hepatitis B antigenemia, and zinc deficiency. To clarify this problem, we studied 64 children with Down syndrome (DS) compared with an age-matched control group. All children had always lived at home. All the DS children were negative for hepatitis B surface antigen. Serum zinc concentration in the DS group was on average 12 pg/dl lower than age-matched control children. They also had significantly lower levels of immunoglobulin M, total lymphocyte count, T and B lymphocytes, and T helper and suppressor cells. In vitro lymphocyte response to phytohemagglutinin and concanavalin A was significantly reduced at all ages in the DS group. Lymphocyte response to pokeweed mitogen increased with age in control children but decreased in the DS children. By 18 yr, the mean response for DS was 60000 cpm lower than controls. The DS group had significantly higher concentrations of immunoglobulins A and G than controls and the difference increased with age. Complement fractions C3 and C4 were also higher in the DS group at all ages. The number of HNK-1 positive cells was higher in the DS group than controls at all ages. When hepatitis and institutionalization are excluded a s confounding factors, DS children still differ in both humoral and cell-mediated immunity from an age-matched control group. (Pediatr Res 22: 536-540, 1987)

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Age-Related Changes in Humoral and Cell- Mediated Immunity in Down Syndrome Children Living at Home

et al. 1987

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“…Individuals with Down's syndrome have a relative immune deficiency (Albin 1978) and there is an increased susceptibility to all infections in particular those of the respiratory tract. Strict asepsis is advisable for invasive procedures and venous and arterial cannulas, urinary catheters etc.…”

Section: Immunity and Haematologymentioning

confidence: 99%

Down's syndrome and anaesthesia

Mitchell

Howard

Facer

1995

Pediatric Anesthesia

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Down's syndrome is a common congenital abnormality associated with characteristic morphological features, impaired intellectual development and disorders of many organ systems with a broad spectrum of severity. Many of these, including defects in cosmetic appearance, are amenable to surgical correction. The risks of anaesthesia are increased in these children. In this article the anaesthetic implications of the syndrome are reviewed and the principles of perioperative management discussed.

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The Patient With Down’s Syndrome

Sofair¹

1991

Preanesthetic Assessment 3

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Immunity in Down's syndrome

Cited by 5 publications

References 8 publications

Age-Related Changes in Humoral and Cell- Mediated Immunity in Down Syndrome Children Living at Home

Age-Related Changes in Humoral and Cell- Mediated Immunity in Down Syndrome Children Living at Home

Down's syndrome and anaesthesia

The Patient With Down’s Syndrome

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