Immunity in Infection with Neisseria gonorrhoeae: Duration and Serological Response in the Chimpanzee

Arko, R J; Duncan, W. P.; Brown, W. J.; Peacock, William L.; Tomizawa, Takayuki

doi:10.1093/infdis/133.4.441

Cited by 36 publications

(17 citation statements)

References 19 publications

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“…Recent observation on the effect of systemic immunization of chimpanzees with killed gonococci supports the idea that antibodies provide effective protection against experimental intraurethral infection by N. gonorrhoeae (Arko, Duncan, Brown, Peacock, and Tomizawa, 1976). Hovever, the recent observation of O'Reilly and others (1976) that female patients with recurrent gonococcal cervicitis had high titres of serum antibody at the time of re-infection argues against the protective value of serum antibody.…”

Section: Discussionmentioning

confidence: 94%

Serum and secretory antibody responses to Neisseria gonorrhoeae in patients with gonococcal infections.

Tapchaisri¹,

Sirisinha²

1976

Sexually Transmitted Infections

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Section: Discussionmentioning

confidence: 94%

Serum and secretory antibody responses to Neisseria gonorrhoeae in patients with gonococcal infections.

Tapchaisri¹,

Sirisinha²

1976

Sexually Transmitted Infections

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“…gonorrhoeae is a human-specific pathogen. Animal models that have been used to simulate disease in humans by inoculating gonococci into their genital tracts include the chimpanzee (2,42,43), which can sustain a gonococcal infection, and more recently the 17-␤-estradiol-treated mouse (44). Attempts to infect the genital tracts of baboons, monkeys, rabbits, and guinea pigs have not been successful.…”

Section: Discussionmentioning

confidence: 99%

Human C4b-binding protein selectively interacts withNeisseria gonorrhoeaeand results in species-specific infection

Ngampasutadol

Ram

Blom

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease that is restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind the classical pathway of complement down-regulatory protein C4b-binding protein (C4bp) to evade killing by human complement. Strains of N. gonorrhoeae that resisted killing by human serum complement were killed by serum from rodent, lagomorph, and primate species, which cannot be readily infected experimentally with this organism and whose C4bp molecules did not bind to N. gonorrhoeae. In contrast, we found that Yersinia pestis, an organism that can infect virtually all mammals, bound speciesspecific C4bp and uniformly resisted serum complement-mediated killing by these species. Serum resistance of gonococci was restored in these sera by human C4bp. An exception was serotype Por1B-bearing gonococcal strains that previously had been used successfully in a chimpanzee model of gonorrhea that simulates human disease. Por1B gonococci bound chimpanzee C4bp and resisted killing by chimpanzee serum, providing insight into the host restriction of gonorrhea and addressing why Por1B strains, but not Por1A strains, have been successful in experimental chimpanzee infection. Our findings may lead to the development of better animal models for gonorrhea and may also have implications in the choice of complement sources to evaluate neisserial vaccine candidates. complement ͉ gonorrhea

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“…Until now, the chimpanzee was the only animal host that facilitated the study of gonococcal urethral infection [8][9][10][11]. Of interest, male chimpanzees parenterally inoculated with a formaldehyde-treated whole-cell vaccine developed a strain-related resistance to gonococcal challenge [12]. However, the cost and availability of chimpanzees limits the use of this model of infection.…”

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confidence: 99%

Intranasal Immunization with Gonococcal Outer Membrane Preparations Reduces the Duration of Vaginal Colonization of Mice byNeisseria gonorrhoeae

et al. 2000

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Nasal immunization was studied to determine if it could elicit an immune response capable of preventing vaginal colonization by Neisseria gonorrhoeae or of reducing its duration in the estradiol-treated mouse model. Nasal administration of gonococcal outer membrane (OM) preparations induced the development of systemic and vaginal immune responses that were directed mainly against a limited number of gonococcal OM proteins. The impact of nasal immunization on vaginal colonization by N. gonorrhoeae was evaluated by use of an experimental model, in which mice were treated with estradiol to prolong the infection. Bacterial clearance was significantly faster for mice immunized intranasally with N. gonorrhoeae OM preparations (4.0+/-2.5 days) than for control mice (8.5+/-4.3 days). The estradiol-treated mouse model may serve as a useful tool for the evaluation of potential gonococcal vaccine candidates.

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Immunity in Infection with Neisseria gonorrhoeae: Duration and Serological Response in the Chimpanzee

Cited by 36 publications

References 19 publications

Serum and secretory antibody responses to Neisseria gonorrhoeae in patients with gonococcal infections.

Serum and secretory antibody responses to Neisseria gonorrhoeae in patients with gonococcal infections.

Human C4b-binding protein selectively interacts withNeisseria gonorrhoeaeand results in species-specific infection

Intranasal Immunization with Gonococcal Outer Membrane Preparations Reduces the Duration of Vaginal Colonization of Mice byNeisseria gonorrhoeae

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