Immunity Mechanisms in Neurological Disease

On cerebrospinal fluid immunoglobulin-G (IgG) quotients in multiple sclerosis and other diseases

“…KABAT et al (1942), BURTIN (1960BURTIN ( , 1964, McMENEMEV (1961), LATERRE (1965) and LUMSDEN (1965a) have shown that alterations in the composition of the protein components of serum are reflected in the CSF. In particular McMENEMEY (1961) found in myelomatosis that the serum protein elevations might relate to "typical" ~-globulin and to ~2-globulin, but the principal increase may be in an abnormal fi-globulin fraction occupying an intermediary position between fl and 7-In each of the instances where these fractions of the serum proteins were increased in myelomatosis, MCMENEMEY found the same component disproportionately elevated in the CSF.…”

Mollaret meningitis: Report of a case with recovery after colchicine

“…Despite the time that has passed since benign recurrent endothelioleukocytic meningitis was first described, little is known about its pathophysiology. The importance of inflammatory phenomena and immunological mechanisms in the manifestation of the disease are underlined in our patient by the high levels of IgG and IgM in CSF, which are not seen in viral meningitis until late in the disease [14]; by the elevation in CSF of alpha-2 globulin, with normal values of albumin, characteristic of tissue damage or inflammation in the central nervous system [7]; and by the resolution of clinical and CSF symptoms following administration of an agent that inhibits the cellular inflammatory response 14, 51.…”