Immunity to Haemophilus influenzae type b on sample population from central Italy

Strömberg, Anna; Rappuoli, Rino; Viti, S; Costantino, Paolo; Fanti, O; Cellesi, C

doi:10.1016/0264-410x(92)90445-p

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…It was reported that natural immunity to Hib increases cumulatively with age 20,23,24 . In our study, the natural immunity rates were high even in very early ages, therefore a significant increase could not be found in the levels of natural immunity with increasing age.…”

Section: Discussioncontrasting

confidence: 73%

“…21,22 It was reported that natural immunity to Hib increases cumulatively with age. 20,23,24 In our study, the natural immunity rates were high even in very early ages, therefore a significant increase could not be found in the levels of natural immunity with increasing age. In other studies performed in Turkey, the higher natural immunity rates were found more frequently in the very young (natural immunity rates of the same children at 6.5 and 13 months was 53.7% and 69.6%, respectively, yet in another study on children between 6 and 12 months the rate was 91%).…”

Section: Discussioncontrasting

confidence: 55%

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Natural immunity to Haemophilus influenzae type B in children of Ankara, Turkey

Ocaktan¹,

Özyurda²,

Akar

2004

Pediatrics International

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Section: Discussioncontrasting

confidence: 73%

Section: Discussioncontrasting

confidence: 55%

Natural immunity to Haemophilus influenzae type B in children of Ankara, Turkey

Ocaktan¹,

Özyurda²,

Akar

2004

Pediatrics International

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“…The present results show that most Japanese infants who are not protected with Hib‐conjugate vaccines are susceptible to Hib diseases, and this finding is consistent with those of other studies 7,13 . We found that the prevalence of natural immunity to Hib was lowest in children under 1 year of age and gradually increased with age.…”

Section: Discussionsupporting

confidence: 93%

Quantitative measurements of Hemophilus influenzae type b capsular polysaccharide antibodies in Japanese children

Ishiwada¹,

Fukasawa²,

Inami³

et al. 2007

Pediatrics International

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Approximately half of Japanese children are not protected against Hib infection. Therefore, Hib vaccine should immediately be included as part of the routine immunization program in Japan. It was also found that all tested commercially available immune globulin preparations had high anti-CP titers. Well-controlled clinical trials of i.v. immune globulin administration for prevention and treatment of Hib systemic infection are needed in Japan.

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“…with time since response [36,37]. This slowing, together with the effect of new stimuli, helps to explain the stability of adult Hib antibody concentration levels, the mean concentration in many populations being around 1-2 µg\ml [15,27,38,39]. Even allowing for some uncertainty regarding the antibody concentration protective for invasive disease, it seems that in the majority of people the duration of protective immunity after active immunization (Hib polysaccharide vaccine or natural infection) is about a decade, even when the force of infection is very low (λ l 0).…”

Section: Duration Of Immunity To Invasive Diseasementioning

confidence: 98%

Dynamics of natural immunity caused by subclinical infections, case study on Haemophilus influenzae type b (Hib)

et al. 2000

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Natural immunity to Haemophilus influenzae type b (Hib) is based primarily on antibodies that are thought to develop in response to subclinical infections. Wide use of conjugated Hib vaccines could lead to decreases in circulating Hib bacteria, thereby diminishing antibody levels in the unvaccinated. We applied a statistical model to estimate the duration of natural immunity to Hib under different forces of infection. Prior to the introduction of conjugated Hib vaccines, new Hib infections were estimated to occur once in 4 years and the antibody concentration to stabilize at a level around 1 microg/ml. In the absence of new stimuli, i.e. infection, 57% of the unvaccinated population would become susceptible to invasive disease (antibody levels < 0.15 microg/ml) in 10 years. Due to an interaction between the force of infection and the duration of immunity, in some situations numbers of invasive infections could increase in unvaccinated cohorts. This theoretical scenario has yet to be observed in practice.

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Immunity to Haemophilus influenzae type b on sample population from central Italy

Cited by 10 publications

References 26 publications

Natural immunity to Haemophilus influenzae type B in children of Ankara, Turkey

Natural immunity to Haemophilus influenzae type B in children of Ankara, Turkey

Quantitative measurements of Hemophilus influenzae type b capsular polysaccharide antibodies in Japanese children

Dynamics of natural immunity caused by subclinical infections, case study on Haemophilus influenzae type b (Hib)

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