1976
DOI: 10.1017/s0031182000048472
|View full text |Cite
|
Sign up to set email alerts
|

Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters

Abstract: In young (6- to 8-week-old) NTH strain inbred mice expulsion of a primary infection of Trichinella spiralis began on day 8 and was virtually complete by day 11·5. In older mice expulsion occurred 1 or 2 days earlier. Experience of a primary infection elicited strong immunity to challenge, whether the challenge was given immediately after worm expulsion (day 14) or delayed (day 42). Challenge infections were expelled rapidly, the majority of worms being lost during the first day. Immunity to challenge was elici… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
86
0

Year Published

1983
1983
2016
2016

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 131 publications
(88 citation statements)
references
References 22 publications
2
86
0
Order By: Relevance
“…Mice that have previously experienced a T. spiralis infection will respond in a classical way to a challenge infection by mounting an accelerated and amplified immune response (29). Mast cell numbers and serum mMCP-1 levels were significantly higher at day 3 after infection in secondary infected animals than numbers at day 3 after primary infection.…”
Section: Abrogation Of Mast Cells Blocks Increased Mucosal Permeabilitymentioning
confidence: 99%
“…Mice that have previously experienced a T. spiralis infection will respond in a classical way to a challenge infection by mounting an accelerated and amplified immune response (29). Mast cell numbers and serum mMCP-1 levels were significantly higher at day 3 after infection in secondary infected animals than numbers at day 3 after primary infection.…”
Section: Abrogation Of Mast Cells Blocks Increased Mucosal Permeabilitymentioning
confidence: 99%
“…L1 muscle larvae were obtained after artificial digestion following the method described by Wakelin and Lloyd (1976). After selection of live larvae by the Baermann method, they were washed 10 times by sedimentation in PBS pH 7.2-7.4.…”
Section: Preparation Of Larval Crude Extracts (Lce)mentioning
confidence: 99%
“…In vitro evaluation of GA Adult worms were recovered (Wakelin & Lloyed, 1976). Briefl y, mice were infected orally by 250 Trichinella L1 larvae.…”
Section: In Vivo Experimentsmentioning
confidence: 99%