Immunity to the microbiota promotes sensory neuron regeneration

Enamorado, Michel; Kulalert, Warakorn; Han, Seong-Ji; Rao, Indira; Delaleu, Jérémie; Link, Verena M.; Yong, Daniel; Smelkinson, Margery; Gil, Louis; Nakajima, Saeko; Linehan, Jonathan L.; Bouladoux, Nicolas; Wlaschin, Josette J; Kabát, Juraj; Kamenyeva, Olena; Deng, Liwen; Gribonika, Inta; Chesler, Alexander T.; Chiu, Isaac M.; Pichon, Claire E. Le; Belkaid, Yasmine

doi:10.1016/j.cell.2022.12.037

Cited by 60 publications

(34 citation statements)

References 75 publications

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“…IL-17 has been suggested to negatively impact neurogenesis (Liu et al, 2014), but recent evidence also suggests that it can induce neuron regeneration in the gut barrier (Enamorado et al, 2023). In vitro studies have shown that Th17-derived IL-17 and IL-22 can penetrate the BBB and promote neuron death in (Kebir et al, 2007;Wojkowska, Szpakowski & Glabinski, 2017).…”

Section: T Cells and Age-related Cognitive Impairmentmentioning

confidence: 99%

Update on the Role of T Cells in Cognitive Impairment

Ruiz-Fernandez

Sánchez-Díaz

Ortega-Sollero

et al. 2023

Preprint

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The central nervous system (CNS) has long been considered an immune-privileged site, with minimal interaction between immune cells, particularly of the adaptive immune system. Previously, the presence of immune cells in this organ was primarily linked to events involving disruption of the blood-brain barrier (BBB) or inflammation. However, current research has shown that immune cells are found patrolling CNS under homeostatic conditions. Specifically, T cells of the adaptive immune system are able to cross the BBB and are associated with aging and cognitive impairment. In addition, T-cell infiltration has been observed in pathological conditions, where inflammation correlates with poor prognosis. Despite ongoing research, the role of this population in the aging brain under both physiological and pathological conditions is not yet fully understood. In this review, we provide an overview of the interactions between T cells and other immune and CNS parenchymal cells, and examine the molecular mechanisms by which these interactions may contribute to normal brain function and the scenarios in which disruption of these connections lead to cognitive impairment. A comprehensive understanding of the role of T cells in the aging brain and the underlying molecular pathways under normal conditions could pave the way for new research to better understand brain disorders.

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Section: T Cells and Age-related Cognitive Impairmentmentioning

confidence: 99%

Update on the Role of T Cells in Cognitive Impairment

Ruiz-Fernandez

Sánchez-Díaz

Ortega-Sollero

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…An extraordinary recent study by Enamorado et al 1 . has, for the first time, demonstrated that immunity to the microbiota enhances repair of sensory nerves and epithelial tissues within the skin.…”

Section: Figurementioning

confidence: 99%

“…Enamorado et al 1 . demonstrated that topically applied SA, of a known commensal strain, could effectively colonize mouse skin and generate commensal‐specific Th17 cells.…”

Section: Figurementioning

confidence: 99%

“…An extraordinary recent study by Enamorado et al 1 has, for the first time, demonstrated that immunity to the microbiota enhances repair of sensory nerves and epithelial tissues within the skin. Colonization of the skin by Staphylococcus aureus (SA) generated commensal-specific interleukin (IL)-17-producing CD4 + T helper 17 (Th17) cells that accelerated repair of cutaneous nerve fibers and restored normal sensory thresholds.…”

mentioning

confidence: 99%

“…Enamorado et al 1 demonstrated that topically applied SA, of a known commensal strain, could effectively colonize mouse skin and generate commensal-specific Th17 cells. Highdimensional transcriptomic analysis revealed that tissue protective and regenerative functions were induced by the type 17 immunity.…”

mentioning

confidence: 99%

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A dual role of microbiota type 17 immunity in tissue repair and pain

2023

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Neuro‐Immunomodulatory Potential of Nanoenabled 4D Bioprinted Microtissue for Cartilage Tissue Engineering

Couto,

Vasconcelos,

Pereira

et al. 2024

Adv Healthcare Materials

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Cartilage defects trigger post‐traumatic inflammation, leading to a catabolic metabolism in chondrocytes and exacerbating cartilage degradation. Current treatments aim to relieve pain but fail to target the inflammatory process underlying osteoarthritis progression. Here, we 4D‐bioprint a human cartilage microtissue (HCM) nanoenabled with ibuprofen‐loaded poly(lactic‐co‐glycolic acid) nanoparticles (ibu‐PLGA NPs) to locally mitigate inflammation and impair nerve sprouting. Under in vitro inflamed environment, the nanoenabled HCM exhibits chondroprotective potential by decreasing the interleukin (IL)1β and IL6 release, while sustaining extracellular matrix (ECM) production. In vivo assessments utilizing the air pouch mouse model affirmed the nanoenabled HCM non‐immunogenicity. Nanoenabled HCM‐derived secretome did not elicit a systemic immune response and decreases locally the recruitment of mature dendritic cells and the secretion of multiple inflammatory mediators and matrix metalloproteinases, when compared to inflamed HCM condition. Notably, the nanoenabled HCM secretome had no impact on the innervation profile of the skin above the pouch cavity, suggesting a potential to impede nerve growth. Overall, HCM nanoenabled with ibu‐PLGA NPs emerges as a potent strategy to mitigate inflammation and protect ECM without triggering nerve growth, introducing an innovative and promising approach in the cartilage tissue engineering field.This article is protected by copyright. All rights reserved

show abstract

Immunity to the microbiota promotes sensory neuron regeneration

Cited by 60 publications

References 75 publications

Update on the Role of T Cells in Cognitive Impairment

Update on the Role of T Cells in Cognitive Impairment

A dual role of microbiota type 17 immunity in tissue repair and pain

Neuro‐Immunomodulatory Potential of Nanoenabled 4D Bioprinted Microtissue for Cartilage Tissue Engineering

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