Immunization in state of siege: the importance of thermostable vaccines for Ukraine and other war-torn countries and territories

Tsagkaris, Christos; Laubscher, Lily; Papadakis, Marios; Vladychuk, V.; Matiashova, Lolita

doi:10.1080/14760584.2022.2067146

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Furthermore, it is difficult to predict at what pace vaccine development and availability on a global scale will take place in any future pandemic. Apart from this wide gap in vaccine availability in different parts of the world, economic and political issues remain a concern affecting the success of vaccination programs [ 51 , 52 , 53 , 54 ]. Further to this, there are instances when vaccination can be dangerous if not given under proper recommendation.…”

Section: Why Target Viral Enzymes?mentioning

confidence: 99%

Yeast-Based Screening of Anti-Viral Molecules

Srivastava,

Kumar,

Ahmad

2024

Microorganisms

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Viruses are minuscule infectious agents that reproduce exclusively within the living cells of an organism and are present in almost every ecosystem. Their continuous interaction with humans poses a significant threat to the survival and well-being of everyone. Apart from the common cold or seasonal influenza, viruses are also responsible for several important diseases such as polio, rabies, smallpox, and most recently COVID-19. Besides the loss of life and long-term health-related issues, clinical viral infections have significant economic and social impacts. Viral enzymes, especially proteases which are essential for viral multiplication, represent attractive drug targets. As a result, screening of viral protease inhibitors has gained a lot of interest in the development of anti-viral drugs. Despite the availability of anti-viral therapeutics, there is a clear need to develop novel curative agents that can be used against a given virus or group of related viruses. This review highlights the importance of yeasts as an in vivo model for screening viral enzyme inhibitors. We also discuss the advantages of yeast-based screening platforms over traditional assays. Therefore, in the present article, we discuss why yeast is emerging as a model of choice for in vivo screening of anti-viral molecules and why yeast-based screening will become more relevant in the future for screening anti-viral and other molecules of clinical importance.

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Section: Why Target Viral Enzymes?mentioning

confidence: 99%

Yeast-Based Screening of Anti-Viral Molecules

Srivastava,

Kumar,

Ahmad

2024

Microorganisms

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“…High vaccine wastage rates have been reported in the region due to the disruption of supply chains and the destruction of critical facilities. 8 There are also global shortages of the necessary immunizations, with vaccine equity again being raised in public discussions. 9 • The risk for vulnerable populations is maximized due to the general limitations towards access to all aspects of healthcare.…”

Section: The Challenges Around the Prevention And Control Of Mpx In E...mentioning

confidence: 99%

No health issue stands alone in Eastern Europe: Monkeypox emergence amidst socioeconomic and political crises

Tsagkaris

Matiashova

Essar

et al. 2022

Journal of Medical Virology

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“…Several methods have been tested; some look promising [ 16 , 17 , 18 , 19 , 20 ]. Owing to new and modern challenges in the form of geopolitics (wars, sanctions), vaccine manufacturers and developers should also pay attention to these issues [ 21 ]. Whether a given approach is specific to a given vaccine or formulation or suitable for different vaccine formulations must be tested [ 22 ].…”

mentioning

confidence: 99%