Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection

A study of recombinant protectiveH. pyloriantigens

“…Moreover, in animal model, Balb/c mice immunized with the recombinant fusion protein were protected against H. pylori infection. These were consistent with previous reports [23][24][25][26] . While being an immunogenic marker, M r 26000 OMP showed a high sensitivity and specificity [27] .…”

Th immune response induced byH pylorivaccine with chitosan as adjuvant and its relation to immune protection

“…Mohammadi et al [17] found that stimulating immune response to Th2 could reduce the number of H pylori and the intensity of inflammation of gastric mucosa, indicating that if the type of immune response induced by immunization has changed from Th1 to Th2, H pylori colonization in gastric mucosa can be inhibited by producing Th2 cytokines such as IL-4. Saldinger et al [18] immunized H. felis -infected mice with oral rUreB and CT, and found that infected mice were cured 3 wk after the 4th immunization. they also found that immunization could lead to the proliferation of CD4 + T cells in the spleen of mice accompanying gradual decrease in IFN-γ and increase in IL-4, indicating that immunization of mice with rUreB and CT could induce gradual Th2 immune 14.48 ± 6.84 a F = 0.739 F = 7.948 F = 6.083 F = 6.228 F = 4.189 P = 0.544 P = 0.002 P = 0.006 P = 0.005 P = 0.023 a P < 0.05 vs (1) and (2) groups; b P < 0.01 vs (1) and (2) (2) and (5) groups, h P < 0.01 vs (1), (2) and (5) www.wjgnet.com response , thus eliminating H. felis.…”

Colonization of C57BL/6J and BALB/c Wild-Type and Knockout Mice withHelicobacter pylori: Effect of Vaccination and Implications for Innate and Acquired Immunity

“…(i) The H. pylori infection is characterized by a polarized T-helper cell type 1 (Th1) response that seems to be correlated with pathogenesis (4,12,31,33,49). (ii) If we assume that Th1-Th2 polarization is a paradigm that has the potential to misroute (2), a shift from a Th1 towards a Th0 or a Th2 response seems to be a prerequisite for protection against the H. pylori infection (34,42). (iii) major histocompatibility complex class IIrestricted CD4 ϩ T cells rather than major histocompatibility complex class I-restricted CD8 ϩ T cells are critical for host protection (15,38).…”