Immunization of Mice with Cobalt-60 Irradiated Schistosoma Mansoni Cercariae *

Induction of resistance to Schistosoma mansoni infection in mice by purified parasite paramyosin.

“…Although resistance to S. mansoni in mice can be induced by irradiated cercariae (17), the protective parasite components are unknown. On the other hand, the development of monoclonal antischistosome antibodies that adoptively confer resistance has led to characterization of several potential protective antigens.…”

Immunization with Schistosoma mansoni 22.6kDa antigen induces partial protection against experimental infection in a recombinant protein form but not as DNA vaccine

“…Several studies are in progress in this field, testing different antigens of the parasite and different vaccination strategies . So far, the model that uses irradiated cercariae exposure is the vaccination strategy that induces the highest level of protection against challenge with unattenuated cercariae (Minard et al, 1978). Additionally, in this vaccination protocol the lung seems to be the major site of parasite elimination (Coulson and Wilson, 1997).…”

Schistosoma mansoniTOR is a tetraspanning orphan receptor on the parasite surface

“…There are efforts to develop a vaccine against schistosomiasis. Radio-attenuated cercariae induced a high level of protection in animal models (Minard et al 1978 ;Stek et al 1981) and naturally resistant population groups exist (Correa-Oliveira et al 1989, which suggests that development of an effective vaccine is likely to be possible (McManus and Loukas, 2008). There is a list of recombinant proteins that correlate with resistance in human studies and/or have shown efficacy in animal models (McManus and Loukas, 2008).…”