Immunization status of children with HIV: failure to protect a vulnerable population

Zinna, S. S.; Bamford, Alasdair; Cunnington, Aubrey J.; Kampmann, Beate; Lyall, E. G. H.; Menson, EN; Heath, Paul T

doi:10.1111/j.1468-1293.2010.00895.x

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…However, health care staff responsible for immunization delivery may miss opportunities for immunizing HIV-infected children because they are unaware of those recommendations, they are concerned about greater risk with use of vaccines in this population, or other reasons. African [4, 5] and European studies [6,7, 8] found lower immunization coverage of HIV-infected children compared to uninfected peers, while a North American study found equally low vaccine coverage, for both HIV-infected and the HIV-exposed uninfected populations for some vaccines [9]. In a rural South African population, maternal HIV-positive status was independently associated with lower vaccination rates for four vaccines in children 12–23 month of age (BCG, DTP3, poliomyelitis, and hepatitis B) [10].…”

mentioning

confidence: 99%

Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean

Succi

Krauss

Harris

et al. 2013

Pediatric Infectious Disease Journal

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Background Perinatally HIV-infected children (PHIV) may be at risk of undervaccination. Vaccination coverage rates among PHIV and HIV-exposed uninfected children (HEU) in Latin America and the Caribbean were compared. Methods All PHIV and HEU children born from 2002–2007 that were enrolled in a multi-site observational study conducted in Latin America and the Caribbean were included in this analysis. Children were classified as up to date (UTD) if they had received the recommended number of doses of each vaccine at the appropriate intervals by 12 and 24 months of age. Fisher’s exact test was used to analyze the data. Covariates potentially associated with a child’s HIV status were considered in multivariable logistic regression modeling. Results Of 1156 eligible children, 768 (66.4%) were HEU and 388 (33.6%) were PHIV. HEU children were significantly (p<0.01) more likely to be UTD by 12 and 24 months of age for all vaccines examined. Statistically significant differences persisted when the analyses were limited to children enrolled prior to 12 months of age. Controlling for birth weight, sex, primary caregiver education and any use of tobacco, alcohol or illegal drugs during pregnancy did not contribute significantly to the logistic regression models. Conclusions PHIV children were significantly less likely than HEU children to be UTD for their childhood vaccinations at 12 and 24 months of age, even when limited to children enrolled before 12 months of age. Strategies to increase vaccination rates in PHIV are needed.

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mentioning

confidence: 99%

Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean

Succi

Krauss

Harris

et al. 2013

Pediatric Infectious Disease Journal

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“…I dati raccolti in Francia, su una coorte di 331 pazienti, hanno rilevato coperture inferiori rispetto a quelle della popolazione generale; le più frequenti motivazioni riportate sono state la mancata sensibilizzazione da parte del medico curante, la convinzione di non ottenere risultati in termini di efficacia ed il timore di reazioni avverse di tipo immuno-virologico (6). Anche da uno studio condotto a Londra su 75 bambini con infezione da HIV è emerso che questi sono a maggior rischio di incompleta immunizzazione rispetto ai coetanei sani (7). Analoghe valutazioni sono state fatte anche in Italia: un'indagine svolta in tre regioni (Lazio, Campania e Liguria), che aveva l'obiettivo di valutare i tassi di copertura vaccinale (CV) ed il ritardo nel completamento delle vaccinazioni obbligatorie e raccomandate in bambini portatori di alcune patologie croniche (diabete mellito di tipo 1, fibrosi cistica, disturbi neurologici, sindrome di Down ed infezione da HIV), ha rivelato che, su 275 pazienti, la CV a 24 mesi di vita era solo dell'85% per Difterite-Tetano-Pertosse, Poliomielite ed Epatite B e del 62% per Morbillo-Parotite e Rosolia (8).…”

Section: La Vaccinazione Nel Paziente Con Infezione Da Hivunclassified

La vaccinazione nel paziente con infezione da HIV: attuali raccomandazioni e strategie multidisciplinari per il raggiungimento dei soggetti suscettibili. L’esperienza della Liguria.

Sticchi¹,

Biagio²,

Schiaffino³

et al. 2017

JHA

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“…5 World Health Organization (WHO) dan The Children's HIV Association (CHIVA) menyatakan, pada anak dengan infeksi HIV, imunisasi tetap aman dan bermanfaat meskipun penekanan sistem imun oleh HIV mengurangi manfaat imunisasi bila dibandingkan dengan anak sehat. 5,6,7 Dengan bertambahnya usia anak dengan infeksi HIV, maka respon imun terhadap vaksin akan semakin menurun. Oleh karena itu, imunisasi I sebaiknya dilaksanakan sedini mungkin pada anak-anak yang lahir dari ibu terinfeksi HIV.…”

Section: Pendahuluanunclassified

Faktor-faktor yang memengaruhi status imunisasi pada anak dengan infeksi human immunodeficiency virus

et al. 2016

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Imunisasi merupakan salah satu intervensi kesehatan masyarakat yang secara langsung mengurangi pembiayaan kesehatan. Anak dengan infeksi human immunodeficiency virus (HIV) merupakan populasi yang rentan terhadap penyakit yang dapat dicegah melalui imunisasi sehingga imunisasi sangat direkomendasikan. Kelengkapan status imunisasi pada anak dapat dipengaruhi oleh pendidikan ibu, usia ibu, berat badan lahir, penyakit yang diderita, dan persepsi orangtua. Tujuan penelitian ini adalah untuk mengetahui status imunisasi dasar pada anak dengan infeksi HIV dan faktor-faktor yang berpengaruh. Penelitian ini menggunakan desain potong-lintang. Data didapat dari rekam medis. Analisis data menggunakan metode bivariat dan multivariat dengan tingkat kemaknaan P<0,05. Dari analisis multivariat didapatkan bahwa usia saat diagnosis kurang dari 12 bulan berhubungan dengan status imunisasi pada anak dengan infeksi HIV [RP=0,07 (IK95% 0,02 sampai 0,25), P<0,0001)]. Simpulan dari penelitian ini adalah usia pasien saat didiagnosis dengan infeksi HIV kurang dari 12 bulan merupakan salah satu faktor risiko untuk tidak mendapatkan imunisasi secara lengkap.

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Immunization status of children with HIV: failure to protect a vulnerable population

Cited by 10 publications

References 6 publications

Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean

Undervaccination of Perinatally HIV-infected and HIV-exposed Uninfected Children in Latin America and the Caribbean

La vaccinazione nel paziente con infezione da HIV: attuali raccomandazioni e strategie multidisciplinari per il raggiungimento dei soggetti suscettibili. L’esperienza della Liguria.

Faktor-faktor yang memengaruhi status imunisasi pada anak dengan infeksi human immunodeficiency virus

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