Immunization with Larrea divaricata Cav. proteins elicits opsonic antibodies against Pseudomonas aeruginosa and induces phagocytic activity of murine macrophages

Canale, Fernando P.; Dávila, Silvia del Valle; Sasso, Corina Verónica; Pellarín, Nicolás Wilson; Domínguez, María Aída Mattar

doi:10.1016/j.micpath.2018.03.029

Cited by 6 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been demonstrated that proteins from the crude aqueous extract of L. divaricata administered with adjuvants to mice can induce a good specific immune response, showing crossreaction with proteins of different Gram-negative bacteria such as Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Pseudomonas aeruginosa. In this sense, the IgG and IgA antibodies elicited by immunization with L. divaricata proteins were able to opsonize these bacteria and favor phagocytosis (de Anaya et al, 2009;Sasso et al, 2012;Canale et al, 2018). The anti-L divaricata proteins antiserum can inhibit enzymatic activities of P. aeruginosa such as the hemolytic activity of soluble cell proteins, the protease activity and Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas / 754 extracellular proteins by 100%, 55%-70% and 44% and 95%, respectively (Sasso et al, 2012).…”

Section: Immunomodulatory Effects: Pro-and Antiinflammatory Effectsmentioning

confidence: 99%

Larrea divaricataa native Argentine plant with potential activity against SARS-CoV-2?

Alonso¹,

Marrassini²,

Martin³

et al. 2023

BLACPMA

View full text Add to dashboard Cite

Larrea divaricataCav. is an autochthonous South American plant popularly used in inflammatory and infectious diseases with reported anti-inflammatory, immunomodulatory, antimicrobial and antioxidant activities. Covid-19 is an infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus can cause pneumonia and even death in about 5% of the cases. The objective of the article was to demonstrate, through a literature review, that L. divaricatahas sufficient attributes to be assayed against SARS-CoV-2. For this, the chemical composition, reported activities and docking studies were taken into account. This review demonstrated that the plant extracts are capable of inhibiting the proliferation of fungi, bacteria and viruses and that they exert anti-inflammatory and immunomodulatory actions in different "in vitro" and "in vivo" models. These results suggest that the plant is a good candidate to be studied for the prevention and/or treatment of SARS -CoV-2.

show abstract