Immunmodulation mit Kanne-Brottrunk® zur Prävention bei Pollinosis: Eine einjährige Beobachtungsstudie mit Follow-up

Abstract

The immune enhancing properties of probiotics are scientifically well documented. Whether Kanne- Brottrunk® (Selm-Bork, Germany) may play a preventive role in Pollinosis, was investigated in this study for the first time. Participants and Methods: 30 volunteers with pollinosis and a mean disease duration of 20 years agreed to consume 0.7 l Kanne-Brottrunk® daily for one year. At the beginning and at the end of the study and one year later they retrospectively rated their pollinosis related quality of life during the previous pollinosis season with a disease specific questionnaire (FLQA: Freiburg Life Quality Assessment). Additionally, the change was rated directly and status was assessed in November 2002, January 2003, May 2003 and November 2003. Results: 24 volunteers finished the study, although some of them consumed less than 0.7 l daily. 17 out of 20 assessed participants (85%) rated their pollinosis in the treatment year as ‘very much better’ or ‘much better’ (57% in the follow-up year). In 2003, the FLQA showed clinically relevant effect sizes (0.85-2.29) and statistically significant improvements (p < 0.05) for all six scales. In 2004, the improvements were slightly less pronounced (effect sizes 0.89-1.53) and were statistically significant for 4 scales (p < 0.05). 12 patients reported a relevant reduction or cessation of medication and many reported improvements of other immune related conditions Conclusions: The observed improvements under regular daily consumption of Kanne-Brottrunk® were marked and statistically significant. A randomized controlled trial would be necessary to allow causal conclusions.

Degradation of Gluten in Wheat Bran and Bread Drink by Means of a Proline-Specific Peptidase

“…Bread drink originates from Russia ('Kwas') and is produced by subjecting sourdough bread from wheat, rye, or oats to a non-alcoholic lactic acid fermentation for up to six months [16]. Bread drink is mainly consumed because of its healthpromoting effects [17,18] and has reached a considerable sales volume. However, the product contains gluten in a concentration above 20 mg/ kg and can, therefore, not be consumed by CD patients.…”