Immuno biocompatibility and anti-quorum sensing activities of chitosan-gum acacia gold nanocomposite (CS-GA-AuNC) against Pseudomonas aeruginosa drug-resistant pathogen

Exploring the antimicrobial potential of chitosan nanoparticles: synthesis, characterization and impact on Pseudomonas aeruginosa virulence factors

“…4 With its biocompatibility, biodegradability, and adsorption properties, chitosan serves as an integral component in composite materials, contributing to the acquisition of unique characteristics through diverse combinations. [5][6][7][8] Furthermore, CS has demonstrated antimicrobial and anti-biolm properties. In the case of G-bacteria, these effects are attributed to the chelation of bivalent ions (Ca 2+ and Mg 2+ ) from the bacterial outer membrane and electrostatic interactions with the anionic components of lipopolysaccharides.…”

Green Synthesis of Chitosan–Selenium Bionanocomposite with High Biocompatibility and Its Marked Impact on Las B and RhII Genes Expression in Pseudomonas aeruginosa

“…With this objective, the current study is undertaken to evaluate the molecular mechanism inhibition of virulence genes produced by Pseudomonas aeruginosa. P. aeruginosa major Gram-negative, aero bacilli are known to cause a wide range of severe infections with an elevated rate of mortality and morbidity [32] P. aeruginosa infection is often refractory to antibiotic therapy due to multidrug resistance, making it a World Health Organization and U.S. Centers for Disease Control priority pathogen for therapeutic development [33]. P. aeruginosa produces various virulence factors in a coordinated system that enables host colonisation and adaptation [34][35][36].…”