Immuno-epileptology

Saghazadeh, Amene; Rezaei, Nima

doi:10.1080/1744666x.2017.1327351

Cited by 1 publication

(1 citation statement)

References 39 publications

(41 reference statements)

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“…Some experiments have shown that gut microbiota may be involved in both central and peripheral immune growth processes, as well as in the maintenance of the host homeostasis [176,177]. It has been demonstrated that both a large number of cases of epilepsy preserve an immune-related basis and that immunotherapy is effective in retarding the development of epilepsy [178]. Observational studies have also confirmed that patients with epilepsy may obtain benefits from immunotherapy for controlling seizures [179][180][181][182].…”

Section: Gut Microbiota and Epilepsymentioning

confidence: 99%

Crosstalk between peripheral and the brain-resident immune components in epilepsy

Mu¹,

Zhang²,

Gao³

et al. 2022

J. Integr. Neurosci.

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Epilepsy is one of the most common neurology diseases. It is characterized by recurrent, spontaneous seizures and accompanied by various comorbidities which can significantly a fect a person's life. Accumulating evidence indicates an essential pathophysiological role for neuroin lammation in epilepsy, which involves activation of microglia and astrocytes, recruitment of peripheral leukocytes into the central nervous system, and release of some in lammatory mediators, including pro-in lammatory factors and anti-in lammatory cytokines. There is complex crosstalk between the central nervous system and peripheral immune responses associated with the progression of epilepsy. This review provides an update of current knowledge about the contribution of this crosstalk associated with epilepsy. Additionally, how gut microbiota is involved in epilepsy and its possible in luence on crosstalk is also discussed. Such recent advances in understanding suggest innovative methods for targeting the molecules correlated with the crosstalk and may provide a better prognosis for patients diagnosed with epilepsy.

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