Immuno‐probed multiwalled carbon nanotube surface for abdominal aortic aneurysm biomarker analysis

Abstract

Abdominal aortic aneurysm (AAA), a medical complication, occurs when the aortic area becomes swollen and very large. It is mandatory to identify AAA to avoid the breakdown of aneurysms. C‐reactive protein (CRP) has been recognized as one of the biomarkers for identifying AAA due to the possibility of CRP produced in vascular tissue, which contributes to the formation of an aneurysm, and it is elevated in patients with a ruptured AAA. This research work was designed to develop an immunosensor on a multiwalled carbon nanotube (MWCNT)‐modified surface to quantify the CRP level. Anti‐CRP specificity was constructed on the MWCNT surface through a silane linker to interact with CRP. The detection limit of CRP was calculated as 100 pM with an R2 (determination coefficient) value of 0.9855 (y = 2.3446x – 1.9922) on a linear regression graph. The dose‐dependent linear pattern was registered from 200 to 3000 pM and attained the saturation level during binding at 3000 pM. Furthermore, serum‐spiked CRP showed a clear increase in the current response, proving the specific recognition of CRP in biological samples. This designed biosensor identifies CRP at a lower level and can help diagnose AAA.

Ultraconformable Capacitive Strain Sensor Utilizing Network Structure of Single-Walled Carbon Nanotubes for Wireless Body Sensing

“…Moreover, complex deformation behavior such as changes in the heart rate due to dilation of the blood vessels, 8,10 biting occlusion, 11 touch, 12,13 and the degree of joint flexion 14−16 can provide finer details about individual physical and mental health conditions. 7,17 In particular, aortic aneurysm 18,19 and aspiration pneumonia 20,21 represent prime examples of acute diseases that could be detected in this manner, and considerable attention has been paid to monitoring of the complex deformation of living bodies to realize swift diagnosis and treatment of such diseases. To address this issue, existing devices, such as smart watches, smart contact lenses, and smart rings, are of little use because they cannot capture the complex deformations of interest.…”

“…When the fine details of these actions are examined closely, the large data sets that can be collected will be helpful in areas including disease diagnosis, injury prevention, and prosthetic design. − For example, changes in heart rate, blood pressure, and body temperature can provide a fundamental overview of an individual’s health condition. Moreover, complex deformation behavior such as changes in the heart rate due to dilation of the blood vessels, , biting occlusion, touch, , and the degree of joint flexion − can provide finer details about individual physical and mental health conditions. , In particular, aortic aneurysm , and aspiration pneumonia , represent prime examples of acute diseases that could be detected in this manner, and considerable attention has been paid to monitoring of the complex deformation of living bodies to realize swift diagnosis and treatment of such diseases. To address this issue, existing devices, such as smart watches, smart contact lenses, and smart rings, are of little use because they cannot capture the complex deformations of interest.…”