Immuno-protective efficiency of feed-based whole-cell inactivated bivalent vaccine against Streptococcus and Aeromonas infections in red hybrid tilapia (Oreochromis niloticus × Oreochromis mossambicus)

Effect of an Oral Bivalent Vaccine on Immune Response and Immune Gene Profiling in Vaccinated Red Tilapia (Oreochromis spp.) during Infections with Streptococcus iniae and Aeromonas hydrophila

“…Previously, we developed and tested an oral bivalent vaccine that has proven effective in protecting red tilapia— Oreochromis niloticus × Oreochromis mossambicus —from streptococcosis and aeromonasis [ 24 ]. The oral bivalent vaccine was found to give high protection to the host, with a relative percent survival (RPS) of 82.22 ± 3.85% post- S. iniae challenge, 77.78 ± 3.85% post- A. hydrophila, challenge, and 77.78 ± 3.85% after being challenged with the mixture of S. iniae and A. hydrophila .…”

Efficacy of bi-valent whole cell inactivated bacterial vaccine against Motile Aeromonas Septicemia (MAS) in cultured catfishes (Heteropneustes fossilis, Clarias batrachus and pangasius pangasius) in Bangladesh

“…This has also been proven that increased rate of fish survivability by re-immunization of fishes ( Chettri et al, 2015 ; Pretto-Giordano et al, 2010 ). The cumulative mortality in red hybrid tilapia immunized with bi-valent ( A. hydrophila and A. veronii ) vaccine was not more than 17.78% and 22.22% in the groups challenged with S. iniae and A. hydrophila , respectively, according to Monir et al, (2021) . The RPS was found significantly ( p<0.05 ) higher in the bi-valent vaccinated group (82.22 ±3.85%) compared to the other groups.…”

“…Thus, the present study findings further recommend that a bi-valent ( A. hydrophila and A. veronii ) bacterial vaccine is capable to generate higher protective potentiality to MAS disease of freshwater cultured catfish. Monir et al, (2021) found that fish vaccinated with a feed-based bi-valent vaccine ( A. hydrophila and S. iniae ) had a significant ( p< 0.05 ) increase in IgM levels in both the serum and the skin mucus when tested for both antigens throughout the study compared to the control group. It had also been demonstrated that oral vaccination resulted in a higher level of IgM antibody elicitation in the vaccinated group of fishes.…”

Oral vaccination for sustainable disease prevention in aquaculture—an encapsulation approach

“…These dead oral vaccinations are commercially available formalin-inactivated whole-cell vaccines that may be given with or without adjuvants. Although these bacterial vaccines are extremely immuneprotective and inexpensive to make, the exact interaction of antigen and its component in a vaccine that stimulates the immune response along with associated factors should be analyzed well for effectiveness (Monir et al 2021). For example, certain analyses have proven the possible role of lipopolysaccharides in protection aiding in the vaccine's efficacy.…”