Immunoadjuvant properties of glove cornstarch powder in latex‐induced hypersensitivity

Barbarà, Jordi Casabona i; Santais, M. C.; Levy, David A.; Ruff, F; Leynadier, F.

doi:10.1046/j.1365-2222.2003.01573.x

Cited by 19 publications

(15 citation statements)

References 35 publications

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“…Cornstarch powder, an inert substance added to gloves to facilitate donning and removal, has been documented to serve as a carrier for the allergenic NRL proteins and acts as an immunoadjuvant for latex allergy (5,26,29,45,77). Perspiration increases the solubilization and leaching of NRL proteins and their binding to cornstarch particles, leading to increased potential for sensitization (1,5,29).…”

Section: Latex Glovesmentioning

confidence: 99%

“…Latex‐related occupational bronchial asthma is estimated to affect 2.5% of exposed health care and manufacturing workers (1,36,84). The preponderance of latex‐associated respiratory illness appears to be linked to the use of powdered latex gloves (1,7,77,85). Some affected individuals continue to experience asthmatic symptoms even without contact with NRL devices (29).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

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Latex allergy: diagnosis and management

2004

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Latex allergy is an IgE-mediated immediate hypersensitivity response to natural rubber latex (NRL) protein with a variety of clinical signs ranging from contact urticaria, angioedema, asthma, and anaphylaxis. Major allergens include dipped latex products such as gloves and balloons. In highest risk for NRL allergy are patients with spina bifida, but health care workers and others who wear latex gloves are also at risk. NRL allergic patients may also react to fruits/foods, especially banana, kiwi, and avocado. Diagnosis is made by a positive latex RAST and/or skin prick test or challenge test to NRL. Allergen avoidance and substitution and the use of latex-safe devices including synthetic gloves (vinyl, synthetic polyisoprene, neoprene, nitrile, block polymers, or polyurethane) are essential for the affected patient. Accommodation in the workplace may include the use of powder-free, low-allergen NRL gloves or synthetic gloves. These preventive measures have significantly reduced the prevalence of reported reactions to NRL. Hyposensitization is not yet feasible.

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Section: Latex Glovesmentioning

confidence: 99%

Section: Clinical Manifestationsmentioning

confidence: 99%

Latex allergy: diagnosis and management

2004

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“…Endotoxin activity was evaluated in VCSp and NRL‐CSp using the kinetic chromogenic quantitative Limulus amoebocyte lysate assay (Bio Whittaker Europe SPRL, Verviers, Belgium) according to the European Pharmacopoeia. Endotoxin content was 1.3 ng/g of cornstarch for VCSp and 324 ng/g for NRL‐CSp [15].…”

Section: Methodsmentioning

confidence: 99%

“…In a previous report, we had demonstrated that CSp acts as an immunoadjuvant in guinea‐pigs sensitized to NRL by the peritoneal route [15]. In the present study, our aim was to test the hypothesis that CSp could potentiate the immunogenicity of NRL through breathing latex‐bearing CSp.…”

Section: Introductionmentioning

confidence: 93%

Inhaled cornstarch glove powder increases latex‐induced airway hyper‐sensitivity in guinea‐pigs

Barbarà

Santais

Levy

et al. 2004

Clin Experimental Allergy

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“…This view was confirmed in prospective studies showing that NRL is the major contributor to latex aeroallergen in operating rooms (11). Possibly, cornstarch acts as a non‐antigen‐specific adjuvant (12). Furthermore, risk groups for latex allergy were identified (13, 14).…”

Section: The Wrong Trackmentioning

confidence: 99%

IgE-mediated latex allergy - An exciting and instructive piece of allergy history

Niggemann

2010

Pediatric Allergy and Immunology

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Natural rubber latex represents a potent allergen, which for many years had an important impact on occupational health problems but especially on certain risk groups such as spina bifida. Luckily, these problems decreased when powder-free, latex-poor gloves were introduced. Latest data show that in children with spina bifida, who grew up completely latex-free from birth on, sensitization to NRL as well as clinical relevant allergy significantly decreased. Furthermore, sensitization to aeroallergens also went down and even the prevalence of allergic diseases decreased significantly to rates of the general population. This new data clearly indicates that potent allergens (such as latex) in high-risk groups (such as spina bifida) can induce sensitization spreading, and corresponding avoidance can reverse this development. In conclusion, it can be stated that 'new' allergies can suddenly arise, there are allergen-specific risk groups, local IgE-production is also possible in the CNS, allergen avoidance can be very effective in terms of primary prevention, sensitization spreading can be made reversible by effective prevention, and finally, certain allergies can luckily become history within a relatively short period of time. Furthermore, these new findings clearly end the debate about whether patients with spina bifida have a disease-inherited risk for allergy to NRL and show that the cause is the meningi and the multiple surgical interventions - and therefore sequelae can be reversed by implementing preventive measures.

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Immunoadjuvant properties of glove cornstarch powder in latex‐induced hypersensitivity

Cited by 19 publications

References 35 publications

Latex allergy: diagnosis and management

Latex allergy: diagnosis and management

Inhaled cornstarch glove powder increases latex‐induced airway hyper‐sensitivity in guinea‐pigs

IgE-mediated latex allergy - An exciting and instructive piece of allergy history

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