Immunoadsorption patients with multiple sclerosis: an open‐label pilot study

Moldenhauer, Anja; Haas, Judith; Wäscher, Cornelia; Hoffmann, Karl‐Titus; Kiesewetter, H.; Salama, Abdulgabar

doi:10.1111/j.1365-2362.2005.01518.x

Cited by 27 publications

(18 citation statements)

References 34 publications

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“…All patients treated for acute steroid refractory relapsing multiple sclerosis showed a treatment response, which is in line with the existing literature almost exclusively performed with the tryptophan system where response rates of approximately 75% have been reported [6,7]. Our data is in contrast to the report by Moldenhauer et al [8], who could not demonstrate relevant effects using the same adsorber system in a more heterogeneous group of patients with an extended treatment period. In accordance with previous reports treatment for myasthenia gravis was also highly efficient, directly relating to the exclusive relevance of acetylcholine-receptor autoantibodies in this patient as it has been clearly shown before [9e14].…”

Section: Discussionsupporting

confidence: 65%

Immunoadsorption with regenerating systems in neurological disorders – A single center experience

Hohenstein

Passauer

Ziemssen

et al. 2015

Atherosclerosis Supplements

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Section: Discussionsupporting

confidence: 65%

Immunoadsorption with regenerating systems in neurological disorders – A single center experience

Hohenstein

Passauer

Ziemssen

et al. 2015

Atherosclerosis Supplements

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“…Another strategy may deplete pathogenic antibodies by apheresis using dedicated immunoadsorption systems as previously described in myasthenia gravis [58] and in various extra neurological disorders [59]. However, if the value of this technique is less clear in disorders like MS [60, 61], where pathology is broader than a specific antibody, it could be especially suitable to NMO since anti-AQP4 seems to be the pathological core. The strength of these techniques is the specificity of the antigenic absorption with no regard to the class or subclass of antibodies and no fluid replacement [59].…”

Section: Preventive Treatments and Future Avenuesmentioning

confidence: 99%

Plasma Exchange in Severe Attacks of Neuromyelitis Optica

Bonnan¹,

Cabre

2012

Multiple Sclerosis International

115

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Background. Neuromyelitis optica (NMO) attacks are poorly controlled by steroids and evolve in stepwise neurological impairments. Assuming the strong humoral response underlying NMO attacks, plasma exchange (PLEX) is an appropriate technique in severe NMO attacks. Objective. Presenting an up-to-date review of the literature of PLEX in NMO. Methods. We summarize the rationale of PLEX in relation with the physiology of NMO, the main technical aspects, and the available studies. Results. PLEX in severe attacks from myelitis or optic neuritis are associated with a better outcome, depending on PLEX delay (“time is cord and eyes”). NMO-IgG status has no influence. Finally, we build up an original concept linking the inner dynamic of the lesion, the timing of PLEX onset and the expected clinical results. Conclusion. PLEX is a safe and efficient add-on therapy in NMO, in synergy with steroids. Large therapeutic trials are required to definitely assess the procedure and define the time opportunity window.

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“…The group of MS patients included 36 patients with clinically definite MS and 20 patients with a clinical isolated syndrome suggestive of MS. Because these 2 patient groups did not significantly differ in the various experiments, they are combined in this study. The sources of the immunoadsorption eluates are described in detail in a previous publication (26). T-cell assays were performed using PBMCs prepared from 15 untreated patients with MS and 14 healthy controls (Tables S1 and S2).…”

Section: Methodsmentioning

confidence: 99%

Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals

Derfuss

Parikh

Velhin

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

208

172

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Gray matter pathology is increasingly recognized as an important feature of multiple sclerosis (MS), but the nature of the immune response that targets the gray matter is poorly understood. Starting with a proteomics approach, we identified contactin-2/transiently expressed axonal glycoprotein 1 (TAG-1) as a candidate autoantigen recognized by both autoantibodies and T helper (Th) 1/Th17 T cells in MS patients. Contactin-2 and its rat homologue, TAG-1, are expressed by various neuronal populations and sequestered in the juxtaparanodal domain of myelinated axons both at the axonal and myelin sides. The pathogenic significance of these autoimmune responses was then explored in experimental autoimmune encephalitis models in the rat. Adoptive transfer of TAG-1-specific T cells induced encephalitis characterized by a preferential inflammation of gray matter of the spinal cord and cortex. Cotransfer of TAG-1-specific T cells with a myelin oligodendrocyte glycoprotein-specific mAb generated focal perivascular demyelinating lesions in the cortex and extensive demyelination in spinal cord gray and white matter. This study identifies contactin-2 as an autoantigen targeted by T cells and autoantibodies in MS. Our findings suggest that a contactin-2-specific T-cell response contributes to the development of gray matter pathology.cortical pathology ͉ experimental autoimmune encephalitis ͉ Th1/Th17 T cells ͉ node of Ranvier ͉ myelin glycoproteins

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Immunoadsorption patients with multiple sclerosis: an open‐label pilot study

Abstract: Removal of immunoglobulins, including myelin-specific antibodies by immunoadsorption, seems to delay disease progression as defined by EDSS, MSFC and MRI, while the patients' quality of life did not deteriorate.

Cited by 27 publications

References 34 publications

Immunoadsorption with regenerating systems in neurological disorders – A single center experience

Immunoadsorption with regenerating systems in neurological disorders – A single center experience

Plasma Exchange in Severe Attacks of Neuromyelitis Optica

Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals

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