Immunoadsorption with PH-350: As A Beneficial Therapy for Acute Guillain-Barre Syndrome

Abstract

The subjects here were patients (two males and a female) with the severe acute Guillain-Barre Syndrome admitted to our hospital between September 1987 and December 1988. One case was treated with a double filtration plasmapheresis and two cases were with a immunoadsorption. Of the two extracorponeal thrapeutical methods, the clinical efficacies seemed not to be different however biochemical and serological laboratory data showed prominent differences. For instance the large molecular substances in blood; immunoglobulins, coagulating factors and albumin were reduced in plasma levels by the double filtration plasmapheresis, but not or less by the immunoadsorption. Considering the expectable side effects of the two methods, it may say that the immunoadsorption should be applied as a beneficial extracorponeal method for the acute Guillain-Barre Syndrome.

Letter to the editor. Two cases of severe guillain-barré syndrome refractory to double-filtration plasmapheresis but responsive to plasma exchange with fresh frozen plasma (FFP)

“…Though there are several modes of plasmapheresis (PEX) applicable to GBS, no guideline for the selection of mode has been established so far. Recently, plasmapheresis without FFP, e.g., PEX with albumin in place of FFP [3][4], double filtration plasmapheresis (DFPP) [ 5 4 ] , and immunoadsorption [7], were recommended, since their therapeutic efficacies are reportedly equivalent to the prototypic PEX with FFP. In these therapies, FFP-related adverse effects, such as viral infections and hypocalcemic tetany [8], could be avoided.…”