Immunoassay Multiplexing on a Complementary Metal Oxide Semiconductor Photodiode Array

Nagy, Bence; Al-Rawhani, Mohammed A.; Cheah, Boon Chong; Barrett, Michael P.; Cumming, David R. S.

doi:10.1021/acssensors.7b00972

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…SPR measurements have also been demonstrated on the same platform in related works [28,29]. Multimode multiplexing and simultaneous assays have also been achieved [32,35,36]. Altogether, the chip demonstrated to be suitable for four different sensing techniques to be used independently or simultaneously.…”

Section: Discussionmentioning

confidence: 85%

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The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Annese

Accarino

et al. 2019

2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)

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The use of CMOS platforms in medical point-of-care applications, by integrating all steps from sample to data output, has the potential to reduce the diagnostic cost and the time from days to seconds. Here we present the 'Multicorder' technology, a handheld versatile multimodal platform for rapid metabolites quantification. The current platform is composed of a cartridge, a reader and a graphic user interface. The sensing core of the cartridge is the CMOS chip which integrates a 16x16 array of multi-sensor elements. Each element is composed of two optical and one chemical sensor. The platform is therefore capable of performing multi-mode measurements: namely colorimetric, chemiluminescence, pH sensing and surface plasmon resonance. In addition to the reader that is employed for addressing, data digitization and transmission, a tablet computer performs data collection, visualization, analysis and storage. In this paper, we demonstrate colorimetric, chemiluminescence and pH sensing on the same platform by on-chip quantification of different metabolites in their physiological range. The platform we have developed has the potential to lead the way to a new generation of commercial devices in the footsteps of the current commercial glucometers for quick multi-metabolite quantification for both acute and chronic medicines.

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Section: Discussionmentioning

confidence: 85%

“…In [32], we also demonstrate that physical separations fabricated on top of the sensing area enable the use of the Multicorder for simultaneous enzymebased assays of multiple metabolites. Multiplexing immunoassays on the top of the Multicorder chip have also been demonstrated [36].…”

Section: Dmentioning

confidence: 99%

The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Annese

Accarino

et al. 2019

2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)

Self Cite

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“…The LOD of the system was reported 10 µg/ml. Using a device based on CMOS technology offers numerous benefits including, facile large-scale production, high-throughput sensing, high sensitivity, and superior selectivity [89]. As can be seen in Fig.…”

Section: B Opticalmentioning

confidence: 99%

Portable Sensing Devices for Detection of COVID-19: A Review

Sadighbayan

Ghafar-Zadeh

2021

IEEE Sensors J.

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The coronavirus pandemic is the most challenging incident that people have faced in recent years. Despite the time-consuming and expensive conventional methods, point-of-care diagnostics have a crucial role in deterrence, timely detection, and intensive care of the disease's progress. Hence, this detrimental health emergency persuaded researchers to accelerate the development of highly-scalable diagnostic devices to control the propagation of the virus even in the least developed countries. The strategies exploited for detecting COVID-19 stem from the already designed systems for studying other maladies, particularly viral infections. The present report reviews not only the novel advances in portable diagnostic devices for recognizing COVID-19, but also the previously existing biosensors for detecting other viruses. It discusses their adaptability for identifying surface proteins, whole viruses, viral genomes, host antibodies, and other biomarkers in biological samples. The prominence of different types of biosensors such as electrochemical, optical, and electrical for detecting low viral loads have been underlined. Thus, it is anticipated that this review will assist scientists who have embarked on a competition to come up with more efficient and marketable in-situ test kits for identifying the infection even in its incubation time without sample pretreatment. Finally, a conclusion is provided to highlight the importance of such an approach for monitoring people to combat the spread of such contagious diseases.

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“…Nagy et al proposed a CMOS sensor array integrated circuit implemented on a PCB that can perform multiple immunoassays [78]. The front side of the PCB has a 16*16 COMS array of 256 CMOS sensors covering a layer of SU-8 photoresist modified with antigen or antibody bioprobes.…”

Section: Lab-on-pcb For Immunoassaymentioning

confidence: 99%

“…(A) Due to the flexibility of PCB-based circuit, the proposed immunoassay device can easily change the microfluidic channel plate to detect various analytes, and 12 parallel amplification and quantization circuits' schematic diagram is shown in (B), reprinted with permission from[78]. Copyright 2014 Elsevier.…”

mentioning

confidence: 99%

The review of Lab‐on‐PCB for biomedical application

et al. 2020

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Prevention of infectious diseases, diagnosis of diseases, and determination of treatment options all rely on biosensors to detect and analyze biomarkers, which are usually divided into four parts: cell analysis, biochemical analysis, immunoassay, and molecular diagnosis. However, traditional biosensing devices are expensive, bulky, and require a lot of time to detect, which also limited its application in resource‐limited areas. In recent years, Lab‐on‐PCB, which combines biosensing technology and PCB technology, has been widely used in biomedical applications due to its high integration, personalized design, and easy mass production. Among these Lab‐on‐PCB sensing devices, the PCB circuit plays an important role. It can be directly used as a resistance sensor to count cells, and also used as a control device to automatically control the detection device. Flexible PCBs can be used to make wearable medical biosensors. In addition, due to the high degree of integration of the PCB circuit, Lab‐on‐PCB can perform multiple inspections on the same platform, which reduces the inspection time equivalently. Therefore, in this review paper, we discuss the application of Lab‐on‐PCB in four analysis methods of cell analysis, biochemical analysis, immunoassay, and molecular diagnosis, and give some suggestions for improvement and future development trends at the end.

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Immunoassay Multiplexing on a Complementary Metal Oxide Semiconductor Photodiode Array

Cited by 10 publications

References 21 publications

The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

The Multicorder: A Handheld Multimodal Metabolomics-on-CMOS Sensing Platform

Portable Sensing Devices for Detection of COVID-19: A Review

The review of Lab‐on‐PCB for biomedical application

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