Immunobiological efficacy and immunotoxicity of novel synthetically prepared fluoroquinolone ethyl 6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Jantová, Soňa; Paulovičová, Ema; Paulovičová, Lucia; Janošková, Michaela; Panik, Miroslav; Milata, Viktor

doi:10.1016/j.imbio.2017.10.008

Cited by 7 publications

(2 citation statements)

References 63 publications

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“…A new synthetically prepared fluoroquinolone derivative 6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (6FN) could induce RAW 264.7 macrophages cell-release of pro- and anti-inflammatory TH1, TH2 and TH17 cytokines with anti-cancer and/or anti-infection activities. A significant inhibition of growth in cancer cells HeLa was detected [116].…”

Section: Development Of Therapy By Targeting Tamsmentioning

confidence: 99%

The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

Wang

Steger

Mahner

et al. 2019

IJMS

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Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, having a clear understanding of TAMs is essential in treating this disease. In this review, we will discuss the origins and categories of macrophages, the molecules responsible for forming and reeducating TAMs in cervical cancer (CC), the biomarkers of macrophages and the therapy development targeting TAMs in CC research.

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Section: Development Of Therapy By Targeting Tamsmentioning

confidence: 99%

The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

Wang

Steger

Mahner

et al. 2019

IJMS

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“…A complete cell growth inhibition of the tested cell lines was observed at the higher concentrations applied (40–100 μM) after 48–72 hr of incubation. Cell growth inhibition was reported to be a result of apoptosis induction through activation of caspase‐9 and ‐3 . Substitution of ciprofloxacin at the piperazinyl N‐ 4 with aryl and alkyl carbamoylmethyl derivatives yielded potent antiproliferative compounds against non‐small cell lung cancer A549 cell line.…”

Section: Fluoroquinolone Derivatives With Anticancer Activitymentioning

confidence: 99%

Towards anticancer fluoroquinolones: A review article

Abdel-AAl

Abdel‐Aziz

Shaykoon

et al. 2019

Archiv der Pharmazie

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Different studies about the anticancer potential of several medically used antibacterial fluoroquinolones have been established. Fluoroquinolone derivatives, like some anticancer drugs, such as doxorubicin, can achieve antitumor activity via poisoning of type II human DNA topoisomerases. Interestingly, structural features required for the anticancer activity of quinolones have been determined. Most of the chemical modifications required to convert antibacterially acting fluoroquinolones into their anticancer analogs were at position 7 and the carboxylic group at position 3. This review highlights the antitumor potential of fluoroquinolones in general and summarizes the chemical modifications carried out on fluoroquinolones to become anticancer agents. Moreover, the review gives a quick recap on metal ion chelates with fluoroquinolones and their substantial role in topoisomerase poisoning and antitumor potential improvement. Hence, it should be highly interesting for researchers attempting to design and synthesize novel anticancer fluoroquinolone candidates. K E Y W O R D S anticancer, DNA topoisomerase, metal ion complexes, quinolones Arch Pharm Chem Life Sci. 2019;352:1800376.wileyonlinelibrary.com/journal/ardp

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Fluoroquinolones structural and medicinal developments (2013–2018): Where are we now?

Suaifan

Mohammed

2019

Bioorganic & Medicinal Chemistry

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Immunobiological efficacy and immunotoxicity of novel synthetically prepared fluoroquinolone ethyl 6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Cited by 7 publications

References 63 publications

The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

Towards anticancer fluoroquinolones: A review article

Fluoroquinolones structural and medicinal developments (2013–2018): Where are we now?

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