Immunobiology and Application of Aloe vera-Based Scaffolds in Tissue Engineering

Abstract

Aloe vera (AV), a succulent plant belonging to the Liliaceae family, has been widely used for biomedical and pharmaceutical application. Its popularity stems from several of its bioactive components that have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory effects. Given such unique multi-modal biological impact, AV has been considered as a biomaterial for regenerative medicine and tissue engineering applications, where tissue repair and neo-angiogenesis are vital. This review outlines the growing scientific evidence that demonstrates the advantage of AV as tissue engineering scaffolds. We particularly highlight the recent advances in the application of AV-based scaffolds. From a tissue engineering perspective, it is pivotal that the implanted scaffolds strike an appropriate foreign body response to be well-accepted in the body without complications. Herein, we highlight the key cellular processes that regulate the foreign body response to implanted scaffolds and underline the immunomodulatory effects incurred by AV on the innate and adaptive system. Given that AV has several beneficial components, we discuss the importance of delving deeper into uncovering its action mechanism and thereby improving material design strategies for better tissue engineering constructs for biomedical applications.

Evaluating the Effect of Supernatant Collected from the Culture of Bifidobacterium bifidum on the Increase of Angiogenesis in Acute Wound Healing

“…In this study, the culture supernatant of the Bifidobacterium b. showed the potential to increase angiogenesis in the experimental groups. Hence, a comparison of the experimental group 1 and the sham group showed that despite the common hydrogel composition in both dressings and the antibacterial and antiviral properties of the constituents of hydrogels (23,24) in preventing microbial growth and reducing inflammation and pain (8,25), the experimental group 1 has a better performance in the process of wound healing and angiogenesis because of the probiotic agent.…”

Growth Performance, Feed Utilization, Hematological Parameters, and Histological Features of Nile Tilapia (Oreochromis niloticus) Fed Diets with Supplementary Herbal Extracts Under Prolonged Water Exchange

“…Implementing AVE as an additive at the optimum dose stimulates lipase, amylase, and trypsin excretion of the fish gut, so it doesn't use the amino acids as an energy source and is directed to muscle-building (Gabriel et al, 2017). A. vera is a good source of thiamine, riboflavin, folic acid, and essential and non-essential amino acids (Ahlawat and Khatkar, 2011;Darzi et al, 2021). Also, polysaccharides are the major component of A. vera and have been reported to stimulate erythropoiesis (Ni et al, 2004), which can boost the gut microbial community and also improve feed digestibility and availability of nutrients from feedstuffs, and shorten the feed transit time hence there is a beneficial effect on digestive enzymes (Citarasu, 2010;Yu et al, 2018).…”

Biotechnological Applications of Polymeric Nanofiber Platforms Loaded with Diverse Bioactive Materials

“…However, this method still suffers from off-target toxic effects on normal tissue. This increases the need to focus on localized delivery of cytotoxic anticancer agents [106]. Implementation of a biocompatible system after tumour surgery can get rid of remaining residuals and control tumour relapse.…”

“…Implementation of a biocompatible system after tumour surgery can get rid of remaining residuals and control tumour relapse. Nanofiber loaded with anticancer agents can act as a novel effective delivery system for such use due to its large surface area, porosity, and tensile flexibility [48,49,106].…”

“…The cell membrane is destroyed, and the ions penetrate inside to release other cellular components, finally resulting in breakdown of the proton pump and ultimately leading to cell death. EOs can be encapsulated in nanostructures such as nanoparticles [105] and films [106] for enhanced efficacy. Various EOs, including cinnamon, candeia, tea tree, cloves, peppermint, thyme, and lavender, have been incorporated into electrospun nanofibers [107].…”