“…Since the deletion of the V3 loop from gp120 resulted in a drastic decrease of MTCPP binding (Figs 2 and 4), the blocking effect of this compound on mAb 588D binding to gp120 can be mostly ascribed to allosteric effects resulting from MTCPP binding to the V3 loop. This explanation is consistent with the reported reciprocal allosteric interactions between the V3 loop and the CD4 binding site (McKeating et al, 1992;Pinter et al, 1993;Moore et al, 1994), between the gp120 V3 and C2 domains affecting the gp120-gp41 association (Willey and Martin, 1993;Willey et al, 1994;Stamatatos and Cheng-Mayer, 1993), between the V3 and C4 domains (Wyatt et al, 1992;Moore et al, 1993), between the V3 and VUV2 domains (Koito et al, 1994), and the observation that binding of CD4 to gp120 diminished its subsequent association with MTCPP ( Table 2).…”