Immunocompetent cells in resistance to bacterial infections.

Campbell, P A

doi:10.1128/mmbr.40.2.284-313.1976

Cited by 31 publications

(15 citation statements)

References 198 publications

(293 reference statements)

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“…Few authors considered that antibody played a significant role in the induction of crisis forms (but see Jensen et al 1982), and most recent evidence was interpreted as implicating soluble mediators produced by T-cell-activated spleen and liver macrophages and other leucocytes. In other protozoan, metazoan, and bacterial infections where such mediators are effective the evidence suggests that, while these responses may be specifically induced, they are non-specific in effect (Campbell 1976, Edelson 1982, Scott, James & Sher 1985.…”

Section: Introductionmentioning

confidence: 99%

Protective immunity to malaria: studies with cloned lines of rodent malaria in CBA/Ca mice. IV. The specificity of mechanisms resulting in crisis and resolution of the primary acute phase parasitaemia of. Plasmodium chabaudi chabaudi and P. yoelii yoelii

Jarra¹,

Brown²

1989

Parasite Immunology

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Low numbers of parasites from cloned lines of the rodent malaria parasites, Plasmodium chabaudi chabaudi AS and P. yoelii yoelii A, injected into CBA/Ca mice produce acute but usually self-limiting infections. During crisis, i.e. 1-2 days after peak parasitaemia, 'pre-immune' mice experiencing such 'background' infections were reinfected intravenously with homologous parasites or parasites of heterologous strains or species. P. c. chabaudi AS pre-immune mice controlled an AS challenge with essentially the same kinetics as the background infection. Reinfection of AS pre-immune mice with the heterologous (CB and IP-PCI) P. c. chabaudi strains or P. chabaudi adami DS had little effect on the initial growth of these parasites, although eventually the parasitaemia was controlled. In contrast, a partial inhibitory effect on the growth of P. vinckei lentum DS was evident. Challenge with the non-lethal (A) or lethal (YM) variants of P. y. yoelii resulted in an increase in both the growth and virulence of these parasites. P. y. yoelii A pre-immune mice controlled a homologous challenge, but were less effective at controlling the YM variant. In addition, they were unable to clear rapidly a P. c. chabaudi AS or P. v. lentum DS challenge. Both the multiplication and virulence of P. berghei ANKA were enhanced. These findings demonstrate that resolution of the primary acute parasitaemia in P. c. chabaudi AS- and P. y. yoelii A-infected mice is predominantly mediated by species- and strain-specific mechanisms.

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Section: Introductionmentioning

confidence: 99%

Protective immunity to malaria: studies with cloned lines of rodent malaria in CBA/Ca mice. IV. The specificity of mechanisms resulting in crisis and resolution of the primary acute phase parasitaemia of. Plasmodium chabaudi chabaudi and P. yoelii yoelii

Jarra¹,

Brown²

1989

Parasite Immunology

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“…Over the past 11 years, numerous biologically active substances, called lymphokines, have been demonstrated in the supernatants of in vitro cultures of antigenor lectin-activated lymphocytes. These lymphokines have been considered in vitro correlates of cell-mediated immunity and are thought to play a role in host resistance to infectious microorganisms (4,15). Specifically, chemotactic factors and migration inhibition factors have been described which affect the motility of either polymorphonuclear leukocytes (PMN) or cells of the monocyte-macrophage system (4,15,16).…”

mentioning

confidence: 99%

“…These lymphokines have been considered in vitro correlates of cell-mediated immunity and are thought to play a role in host resistance to infectious microorganisms (4,15). Specifically, chemotactic factors and migration inhibition factors have been described which affect the motility of either polymorphonuclear leukocytes (PMN) or cells of the monocyte-macrophage system (4,15,16). Lymphokine-mediated activation of macrophages and monocytes, as measured by enhancement of their metabolic, phagocytic, and bacteriostatic capabilities, has also been reported (6,7,12,17).…”

mentioning

confidence: 99%

Stimulation of polymorphonuclear leukocyte bactericidal activity by supernatants of activated human mononuclear cells

Cross¹,

Lowell²

1978

Infect Immun

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Supematants of phytohemagglutinin-activated human mononuclear cells stimulated polymorphonuclear leukocyte (PMN) activity against the gram-negative organism Serratia marcescens. In the absence of serum opsonins, when control PMN could not impede bacterial growth, stimulated PMN averaged more than 0.6-log kill of the original bacterial inoculum. In the presence of optimal amounts of serum opsonins, when control PMN were significantly bactericidal, stimulated PMN killed, on the average, at least 0.6 log more of bacteria. Stimulation was not found when PMN were preincubated with supernatants for 1 h or less. The data strongly suggested that the action of the PMN stimulating factor was independent of and different from classically described serum opsonins. PMN stimulating activity may be an additional lymphokine-mediated immune defense mechanism enabling hosts to kill invading microorganisms. sequent use. Control cultures, run simultaneously, were identical to the experimental cultures with the 502 on July 31, 2020 by guest http://iai.asm.org/ Downloaded from

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“…From the Surgcal Immunobiology Laboratory, Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio. Classically, macrophage activation is accomplished by the interaction of lymphokines with naive macrophages [5]. These lymphokines are released by T-lymphocytes as a consequence of the binding of specific antigen to the Tcell receptor.…”

Section: Introductionmentioning

confidence: 91%

Macrophage activation and mobilization in nude mice by corynebacterium parvum and pyran: A functional and histologic study

Stinnett

Majeski

1980

Journal of Surgical Oncology

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Peritoneal macrophages from both congenitally athymic ("nude") mice and heterozygous littermates were activated by pyran copolymer or by Corynebacterium parvum vaccine. C parvum did not produce an increase in the number of peritoneal macrophages in nude mice, although it did produce a typical splenomegaly. Pyran produced an even greater influx of macrophages in the peritoneum of nude mice, when compared to normal mice, but did not produce splenomegaly in nude mice. Pyran- and C parvum-induced splenomegaly were accompanied by an increase in the apparent T-cell population of germinal centers. These experiments indicate that: 1) Macrophage activation, per se, by either C parvum, is a thymus-independent event; 2) Macrophage mobilization, as determined by organomegaly or PEC number, does not have an obligatory requirement for T-cells (depending on the agent used); 3) Macrophage activation may not always correlate with mobilization; and 4) Mechanisms for attracting and sequestering macrophages in the peritoneum may be different from those of the spleen.

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Immunocompetent cells in resistance to bacterial infections.

Cited by 31 publications

References 198 publications

Protective immunity to malaria: studies with cloned lines of rodent malaria in CBA/Ca mice. IV. The specificity of mechanisms resulting in crisis and resolution of the primary acute phase parasitaemia of. Plasmodium chabaudi chabaudi and P. yoelii yoelii

Protective immunity to malaria: studies with cloned lines of rodent malaria in CBA/Ca mice. IV. The specificity of mechanisms resulting in crisis and resolution of the primary acute phase parasitaemia of. Plasmodium chabaudi chabaudi and P. yoelii yoelii

Stimulation of polymorphonuclear leukocyte bactericidal activity by supernatants of activated human mononuclear cells

Macrophage activation and mobilization in nude mice by corynebacterium parvum and pyran: A functional and histologic study

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