Immunocyte Depression Induced by Cyclophosphamide in Rats

Göing, H; Günther, Gunnar; Gujarathi, S; Kaiser, P.

doi:10.1159/000230294

Int Arch Allergy Immunol

1970

DOI: 10.1159/000230294

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Immunocyte Depression Induced by Cyclophosphamide in Rats

H Göing¹,

Gunnar Günther²,

S Gujarathi³

et al.

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1972

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Cited by 6 publications

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“…Lymphopenia induced by cyclophosphamide treatment is well known (15)(16)(17)(18). It has previously been shown in this laboratory that cyclophosphamide depletes primarily the small lymphocyte (14,16).…”

mentioning

confidence: 99%

The effect of cyclophosphamide on b and t lymphocytes in patients with connective tissue diseases

Hurd

Giuliano

1975

Arthritis & Rheumatism

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Absolute numbers of B (I&-, IgM-, and IgAstaining) and T lymphocytes (sheep erythrocyte rosetteforming cells) were determined in patients with systemic lupus erythematosus and other connective tissue diseases in cyclophosphamide-treated and noncyclophosphamide-treated patients and in control subjects. I n patients receiving cyclophosphamide, all three types of immunoglobulin-staining varieties of circulating B lymphocytes were significantly decreased. At the same time the circulating T lymphocytes were also significantly reduced. I n patients with scleroderma treated with therapeutic doses of cyclophosphamide and studied sequentially, the reduction in B lymphocytes ocFrom the Dallas Veterans Administration Hospital, Dallas, and T h e Rheumatic

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mentioning

confidence: 99%

The effect of cyclophosphamide on b and t lymphocytes in patients with connective tissue diseases

Hurd

Giuliano

1975

Arthritis & Rheumatism

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Solid tumor models for the assessment of different treatment modalities. XIII. Comparison of response and recovery of host and solid tumor to cyclophosphamide and radiation

Looney

Hopkins

Grover

et al. 1980

Cancer

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A study of the effects of local tumor radiation alone (1500R) and cyclophosphamide alone (150 mg/kg) on the experimental solid tumor rat hepatoma 3924A has been completed. Cyclophosphamide was more effective in controlling tumor growth than either radiation or 5-fluorouracil (5-FU) (150 mg/kg) previously reported. Parallel recovery of bone marrow with increasing animal survival in "split dose" cyclophosphamide toxicity studies (as with 5-FU) indicates that bone marrow is the critical organ for sequential chemotherapy. Recovery of intestinal mucosa following cyclophosphamide (and 5-FU) occurred much earlier than recovery of bone marrow, substantiating the fact that bone marrow is the critical organ governing the time of administration of a second series of chemotherapeutic agents. The longest period of time (seven days) between delivery of radiation and administration of cyclophosphamide resulted in the most effective use of the two modalities. Tumor growth delay was 1.2 times greater than the additive effects of each agent given alone. Radiation and cyclophosphamide given at other time intervals resulted in either an additive or less than additive effect. One of the greatest difficulties to overcome in the more effective clinical use of combined modality therapy is increased toxicity. In these studies, the least host toxicity occurred when the effects of combined radiation and cyclophosphamide on the tumor were greatest. Results of experimental studies to date suggest that sequential combined modality therapy may be given at a time of maximum tumor growth rate that occurs following the previous treatment series. Since the time of maximum tumor growth rate occurs after recovery of the bone marrow from the previous treatment series, combined chemotherapy-radiotherapy schedules of this type should permit sequential administration of chemotherapeutic agents, such as 5-FU and cyclophosphamide, at the time of enhanced tumor sensitivity and diminished host toxicity.

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Versuche zur Beeinflussung des immunologischen Gedächtnisses

Göing

Kaiser

1972

Eur J Immunol

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The elimination of primed antibody‐forming cells and memory cells was examined in Sprague‐Dawley rats after the application of cyclophosphamide. Doses of cyclophosphamide, which completely eliminate virgin sheep red blood cell‐(SRBC)‐specific competent cells, still permit the survival of a fraction of primed cells. In animals devoid of primed cells it is possible to establish SRBC‐specific tolerance upon cyclophosphamide treatment. When SRBC‐primed rats are treated with the drug and subsequently exposed to the antigen, the surviving primed cells are stimulated to proliferation and antibody production, whereas tolerance appears to be induced in the competent cells, which regenerate from the stem cell compartment.

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Immunocyte Depression Induced by Cyclophosphamide in Rats

Cited by 6 publications

References 6 publications

The effect of cyclophosphamide on b and t lymphocytes in patients with connective tissue diseases

The effect of cyclophosphamide on b and t lymphocytes in patients with connective tissue diseases

Solid tumor models for the assessment of different treatment modalities. XIII. Comparison of response and recovery of host and solid tumor to cyclophosphamide and radiation

Versuche zur Beeinflussung des immunologischen Gedächtnisses

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