2012
DOI: 10.1186/1471-2202-13-51
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Immunocytochemical analysis of P2X2 in rat circumvallate taste buds

Abstract: BackgroundOur laboratory has shown that classical synapses and synaptic proteins are associated with Type III cells. Yet it is generally accepted that Type II cells transduce bitter, sweet and umami stimuli. No classical synapses, however, have been found associated with Type II cells. Recent studies indicate that the ionotropic purinergic receptors P2X2/P2X3 are present in rodent taste buds. Taste nerve processes express the ionotropic purinergic receptors (P2X2/P2X3). P2X2/P2X3Dbl−/− mice are not responsive … Show more

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Cited by 23 publications
(23 citation statements)
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References 62 publications
(83 reference statements)
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“…P2X2-/P2X3-immunoreactive terminals may be effective structures for intercellular regulation between adjacent type I cells. The hederiform appearance of P2X2-/P2X3-immunoreactive nerve endings in the CB morphologically resembled those of other sensory cell-nerve complexes, such as P2X3-immunoreactive nerve endings around small intensely fluorescent cells in the superior cervical ganglion (Takaki et al 2015), ramified nerve endings with P2X2 and/or P2X3 immunoreactivities in the neuroepithelial body (Brouns et al 2009), P2X2-/P2X3-immunoreactive ramified nerve endings associated with taste cells in the lingual taste buds (Kataoka et al 2006;Yang et al 2012), and P2X3-immunoreactive nerve endings within laryngeal chemosensory cell clusters (Takahashi et al 2016). The branching pattern of sensory nerve endings with terminal swelling may be common characteristics in sensory cell-nerve complexes.…”
Section: Discussionmentioning
confidence: 79%
“…P2X2-/P2X3-immunoreactive terminals may be effective structures for intercellular regulation between adjacent type I cells. The hederiform appearance of P2X2-/P2X3-immunoreactive nerve endings in the CB morphologically resembled those of other sensory cell-nerve complexes, such as P2X3-immunoreactive nerve endings around small intensely fluorescent cells in the superior cervical ganglion (Takaki et al 2015), ramified nerve endings with P2X2 and/or P2X3 immunoreactivities in the neuroepithelial body (Brouns et al 2009), P2X2-/P2X3-immunoreactive ramified nerve endings associated with taste cells in the lingual taste buds (Kataoka et al 2006;Yang et al 2012), and P2X3-immunoreactive nerve endings within laryngeal chemosensory cell clusters (Takahashi et al 2016). The branching pattern of sensory nerve endings with terminal swelling may be common characteristics in sensory cell-nerve complexes.…”
Section: Discussionmentioning
confidence: 79%
“…Even in the absence of synaptic clefts between type II cells and afferent fibres, ATP secreted into the confined extracellular spaces reaches sufficient concentrations to stimulate P2X receptors on nearby afferent fibres 100 . Interestingly, large ‘atypical’ mitochondria are located directly below the plasma membrane of type II cells near sites where innervating afferent fibres pass in close apposition 111 . These mitochondria are optimally positioned as potential sources of presynaptic ATP for afferent transmission.…”
Section: Neurotransmitters and Modulatorsmentioning
confidence: 99%
“…As mentioned, Type II cells do not exhibit typical synapses. Instead, Type II cells respond to stimuli by releasing adenosine triphosphate (ATP) and acetylcholine through hemichannels Finger et al, 2005;Huang et al, 2007;Romanov et al, 2007) which, in turn, activate purinergic receptors on cranial nerve fibers (Bo et al, 1999;Dando & Roper, 2012;Ogura, 2002;Yang, Montoya, Bond, Walton, & Kinnamon, 2012). Type III cells, however, respond to stimulation by releasing serotonin, norepinephrine and L-aminobutyric acid (Cao, Zhao, Kolli, Hivley, & Herness, 2009;Dvoryanchikov, Huang, Barro-Soria, Chaudhari, & Roper, 2011;Huang, Dando, & Roper, 2009;Huang, Maruyama, Stimac, & Roper, 2008;Huang, Pereira, & Roper, 2011;Obata, Shimada, Sakai, & Saito, 1997).…”
Section: Brief Overview Of Human Taste Perceptionmentioning
confidence: 99%