Immunocytochemical characteristics of submucosal uterine myomas

Mladenovic-Mihailovic, Aleksandra; Mladenovic-Bogdanovic, Zorica; Mitrovic, P.; Tanasković, Irena; Usaj-Knezevic, Slavica; Stanojevic, Marija

doi:10.2298/vsp1012977m

Cited by 2 publications

(6 citation statements)

References 5 publications

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“…Останніми роками проводять все більше досліджень, присвячених зв'язку ЛМ і пролактину. Доведено, що клітини пухлини містять пролактин [13,[23][24][25]27]. Залежність росту ЛМ від вмісту статевих гормонів знаходить підтвердження у збільшенні розмірів пухлини під час вагітності та її регресії після менопаузи.…”

Section: патогенез лмunclassified

“…Це зумовлено етіопатогенетичною роллю прогестерону у розвитку міоми матки та характеризується високими показниками мітотичного індексу у клітинах тканини міоми у лютеїнову фазу. Міому матки виявляють як у пацієнток із нормальним гормональним статусом та овуляторним циклом, так і у хворих із гормональними порушеннями [27][28][29].…”

Section: патогенез лмunclassified

“…У пацієнток з великою ЛМ (більше 20 тиж вагітності) можуть діагностувати синдром нижньої порожнистої вени -серцебиття і задишка у положенні лежачи. Пацієнтки можуть скаржитися на біль, збільшення живота, можлива гостра затримка сечі [26,27].…”

Section: клініко-ультразвукова класифікаціяunclassified

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Uterine leiomyoma: modern aspects of clinic, diagnosis and treatment

Golyanovskiy¹,

Kachur²,

Budchenko³

et al. 2021

RHW

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According to the WHO, neoplastic processes of the uterus remain one of the important and relevant areas of modern gynecology. Uterine leiomyoma is one of the most common tumors of the female reproductive system. According to the latest data, every 4–5th woman in the world is diagnosed with leiomyoma, the incidence of which under the age of 35 reaches 50%, and according to autopsy data reaches 80%.The article provides a review of the scientific publications in recent years devoted to the study of the problem of uterine fibroids – relevance, causes and mechanisms of development, provides a classification, clinical manifestations, modern diagnostics and management tactics.The etiological factors of leiomyoma are numerous, there is no a single theory of the disease. Among the pathogenetic factors of leiomyoma are hormonal disorders, genetic components, infections, injuries. There are several classifications of leiomyoma, the most common classification was proposed by the International Federation of Gynecology and Obstetrics, which reflects the types of leiomatous nodes depending on their location and relationship to the uterine cavity and myometrium.Clinical manifestations of uterine fibroids range from asymptomatic to painful sighns and hemorrhagic syndromes, symptoms of compression of adjacent organs, the development of uterine bleeding, which lead to severe anemia. The nature of clinical features significantly depend on the localization of the leiomyoma nodes in the uterine body and their relationship to the uterine cavity (submucosal, intramural, subserous), as well as their number, size and blood supply.Modern diagnosis of leiomyoma is based on anamnesis, bimanual gynecological examination, ultrasound examination, and in some cases – magnetic resonance imaging and computed tomography examinations, hysteroscopy and laparoscopy. Today, the main methods of treatment of leiomyoma are conservative, surgical and radiological methods (uterine artery embolization, magnetic resonance-guided focused ultrasound).In addition to the listed modern aspects of the clinic, diagnosis and treatment of uterine leiomyoma, the article emphasizes the importance of preventive measures to reduce the incidence of this gynecological pathology.

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Section: патогенез лмunclassified

Section: клініко-ультразвукова класифікаціяunclassified

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Uterine leiomyoma: modern aspects of clinic, diagnosis and treatment

Golyanovskiy¹,

Kachur²,

Budchenko³

et al. 2021

RHW

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“…They were found to consist of SMCs of the highly differentiated contractile and proliferate phenotypes [α-smooth muscle actin (SMA)-, desmin- and proliferating cell nuclear antigen-immunoreactivity], as well as connective tissue as a result of the synthetic activity of the fibroblasts. The two components markedly differ in their immunocytochemical characteristics from SMCs of the synthetic phenotype (13). Furthermore, Moore et al (9) revealed that human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, as well as activate receptor tyrosine kinases and transforming growth factor (TGF)-β-receptor signaling in co-cultures.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it has been proposed that the pathogenesis of myomas is comparable to an injury response (analogous to keloid development) following surgery (12). Mladenović-Mihailović et al (13) investigated the immunocytochemical characteristics of smooth muscle cells (SMCs) and connective tissue components of uterine submucosal myomas. They were found to consist of SMCs of the highly differentiated contractile and proliferate phenotypes [α-smooth muscle actin (SMA)-, desmin- and proliferating cell nuclear antigen-immunoreactivity], as well as connective tissue as a result of the synthetic activity of the fibroblasts.…”

Section: Introductionmentioning

confidence: 99%

Stromal fibroblast activation and their potential association with uterine fibroids (Review)

Zheng

Cai

et al. 2014

Oncology Letters

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Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts in tumor microenvironments have emerged as an important target for cancer therapy. Repeated stimulation by infectious or non-infectious agents in the uterine tissues, including inflammation, mechanical forces or hypoxia, stimulate the resident fibroblasts to undergo specific activation and, thus, are significant in tumorigenesis. Furthermore, complex signaling pathways regulate the mechanisms of fibroblastic activation. The current review focuses on the molecular mechanisms of fibroblastic activation and the potential association with uterine leiomyoma pathogenesis, enabling an integrated pathogenic analysis for review of the therapeutic options.

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Immunocytochemical characteristics of submucosal uterine myomas

Cited by 2 publications

References 5 publications

Uterine leiomyoma: modern aspects of clinic, diagnosis and treatment

Uterine leiomyoma: modern aspects of clinic, diagnosis and treatment

Stromal fibroblast activation and their potential association with uterine fibroids (Review)

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