Immunocytochemical detection of basement membrane antigens in the histopathological evaluation of laryngeal dysplasia and neoplasia

Visser, R.; Beek, J.M.H. van der; Havenith, M. G.; Cleutjens, Jack P.M.; Bosman, F. T.

doi:10.1111/j.1365-2559.1986.tb02472.x

Cited by 50 publications

(19 citation statements)

References 6 publications

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“…Conversely, almost all patients with CIV pattern II staining died by two years: 8 the first year with distant (5) or regional (2) metastasis or both (1); three more patients died the second At three years of evolution, the difference in survival as related to the CIV staining pattern was still highly significant (P<0.001) (Table II). For this statistical analysis, we used the Armitage-Cochran test (Table II) (Ingber et al, 1981), breast (Albrechtsen et al, 1981;Siegal et al, 1981), colon (Burtin et al, 1982;Forster et al, 1984), brain (McArdle et al, 1984), thyroid gland (Miettinen & Virtanen, 1984), melanomas (Natali et al, 1985) and laryngeal specimens (Visser et al, 1986).…”

Section: Resultsmentioning

confidence: 99%

“…Like other epithelia, urothelium is sustained by a basement membrane which separates it from connective tissue and contains various glycoproteins of high molecular weight (Vracko, 1974;Kefalides, 1975;Orkin et al 1977). Among them, type IV collagen (CIV) forms a network which is the architectural skeleton of basement membranes and laminin plays an important role in anchoring epithelial cells to CIV Terranova et al 1980;Timpl et al 1981).…”

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confidence: 99%

“…Later, several groups studied basement membrane antigens in human tumours of different organs using immunohistological methods: Breast (Albrechtsen et al, 1981;Siegal et al, 1981), pancreatic gland (Ingber et al, 1981), colon (Burtin et al, 1982(Burtin et al, et 1983Forster et al, 1984), thyroid gland (Miettinen & Virtanen, 1984), brain (McArdle et al, 1984) melanomas (Natali et al, 1985) and recently laryngeal specimens (Visser et al, 1986), but no study has been reported on bladder tumours. Furthermore, Forster et al (1984) Immunoperoxidase method Antisera to CIV purified from the matrix of EHS sarcoma were raised in rabbits and the antibodies, which were kindly given us by J.M.…”

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confidence: 99%

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Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Daher¹,

Abourachid²,

Bove³

et al. 1987

Br J Cancer

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A prospective study of type IV collagen in urothelial tissues was undertaken using an immunoperoxidase method on 125 ethanol fixed specimens. In normal and non cancerous urothelium, the basement membrane was continuously stained and the same pattern was seen in the 27 superficial carcinomas. In the 48 invasive bladder carcinomas, we observed two patterns of staining for collagen IV: in the first one, the staining line was conserved or partially fragmented (28 tumours), while in the second one the staining line was widely fragmented or absent in more than 5% of the tumour area (20 tumours). We found a highly significant statistical correlation between the pattern of staining and short term prognosis. Twenty-nine patients had an assessable follow-up of three years at least. All 16 patients with pattern I staining were alive at two years while only two out of 13 patients with pattern II staining survived two years (P less than 0.0001). At three years, all the patients with pattern II staining died while 11 patients with pattern I were still alive (P less than 0.001). These data provisionally indicate that the type IV collagen staining pattern may be of prognostic value in assessing the short term behaviour of invasive bladder carcinomas. It is thus logical to envisage that the treatment decisions may be influenced by the results of collagen IV staining. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Daher¹,

Abourachid²,

Bove³

et al. 1987

Br J Cancer

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“…This could be due to lack of synthesis, decreased assembly and the increase turnover or degradation/dissolution of basement membrane components during invasion supporting the concept of Bernstein et al 18 a cyclic behavior of tumor cells adhesion, synthesis and secretion of hydrolytic enzymes in degradation of basement membrane components and the extracellular matrix for cellular invasion. Furthermore Visser et al, 19 Sakr et al 13 also observed similar defects in the basement membrane component exclusively in areas adjacent to inflammatory cells. As these cells were capable of releasing enzymes which digest the basement membrane components.…”

Section: Discussionmentioning

confidence: 81%

Expression of Extracellular Matrix—Laminin in Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Koshy¹,

Rao

Kamat

et al. 2012

The Journal of Contemporary Dental Practice

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Aim:To evaluate the expression of laminin in various grades of oral squamous cell carcinoma (OSCC) in order to determine whether this protein can be used as a marker for early detection and elucidation of oral cancer. Materials and methods:Immunohistochemical staining for laminin was done on 60 selected archival blocks of histopathologically diagnosed cases of primary OSCC and the laminin expression was compared between the different histopathological grades of primary OSCC. The statistical analysis was performed by using Chi-square ( χ square) test and Gaussiantest with a probability of p < 0.05 was considered as significant. Results:It was observed that laminin expression decreased with tumor progression which may be correlated to the tumor aggressiveness. Conclusion:There was a gradual decrease of laminin staining with decreasing cellular differentiation, with differentiated lesions showing a more conspicuous staining of basement membrane glycoprotein than less differentiated lesions.Clinical significance: An understanding of how the extracellular matrix influences tumor development and invasion is fundamental in the development of new prognostic indicators and treatment strategies for oral squamous cell carcinoma.

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“…Although the loss of basement membrane has not been correlated with invasive behaviour of HNSCC [40,41], but a wide variety of proteolytic enzymes and there specifi c inhibitors are reported in the development of tissue invasion and regional metastasis of HNSCC.…”

Section: Introductionmentioning

confidence: 99%

Head and Neck Squamous Cell Cancer: Biology (II) and Translational Methods

Mishra¹,

Pandey²,

Nong

2007

Indian J Otolaryngol Head Neck S

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The essential steps implicated in carcinogenesis are acquisition of autonomous proliferative signaling; inhibition of growth inhibitory signals; evasion of apoptosis; immortalization; angiogenesis; tissue invasion and metastasis. A considerable progress in understanding the process of carcinogenesis has further stimulated the high throughput translational methods and systems biology approach to revolutionize this fi eld of cancer biology. The era of molecular targeted therapy has dawned and would soon replace the more 'toxic' classical 'broad-spectrum' cancer chemotherapy. This review summarises the steps of carcinogenesis and the concepts involved in translational methods, systems-biology and molecular targeted therapy.

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Immunocytochemical detection of basement membrane antigens in the histopathological evaluation of laryngeal dysplasia and neoplasia

Cited by 50 publications

References 6 publications

Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Collagen IV staining pattern in bladder carcinomas: relationship to prognosis

Expression of Extracellular Matrix—Laminin in Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Head and Neck Squamous Cell Cancer: Biology (II) and Translational Methods

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