Immunocytochemical localization of angiotensin-(1–7) in the rat forebrain

Block, Christine H.; Santos, Robson A.S.; Brosnihan, K. Bridget; Ferrario, Carlos M.

doi:10.1016/0196-9781(88)90208-2

Cited by 83 publications

(56 citation statements)

References 22 publications

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“…These data were substantiated by the observation of immunoreactivity against Ang-(1-7) in brain areas associated with hydromineral balance, the hypothalamus and neurohypophysis (13). However, other studies did not provide conclusive data regarding the possible central Ang-(1-7)-AVP interaction suggested by these early reports.…”

Section: Angiotensin-(1-7) and Vasopressinmentioning

confidence: 47%

“…Other findings have indicated that Ang-(1-7) can act as an osmoregulatory peptide. Immunohistochemistry demonstrated that this peptide is present in brain areas related to the control of hydromineral balance (13). Additional studies in our laboratory have demonstrated that Ang-(1-7) has a potent antidiuretic effect in water-loaded rats (14) and that its plasma concentration is increased by hemorrhage or by maneuvers known to increase plasma osmolality such as water deprivation and salt load (15).…”

Section: Introductionmentioning

confidence: 95%

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Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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Section: Angiotensin-(1-7) and Vasopressinmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 95%

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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“…- 19 Additionally, we showed direct neuronal as well as cardiovascular actions of the peptide in the dorsal medulla.…”

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confidence: 96%

Actions of angiotensin peptides after partial denervation of the solitary tract nucleus.

1990

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We determined the excitatory effects of direct nucleus tractus solitarii injection of angiotensin peptides after the sinoaortic nerves were cut unilaterally in rats under halothane anesthesia. Twenty-four hours later, recordings of mean arterial pressure and heart rate were obtained during injections of 2.5 ng angiotensin II or angiotensin-(l-7) in chloralose-urethaneanesthetized rats. Both peptides caused reductions in pressure and heart rate after nucleus tractus solitarii injections. In unilateral sinoaortic denervated rats, the hypotension and bradycardia produced with angiotensin II injections in either the ipsilateral (denervated) or contralateral (nondenervated) nucleus tractus solitarii were comparable. Angiotensin-(l-7), however, produced a larger decrease in pressure on the denervated side when compared with the nondenervated side. There were no differences in baseline pressure or heart rate between control rats and those with unilateral sinoaortic denervations. The effects of both angiotensin II and angiotensin-(l-7) were blocked by previous administration of the angiotensin II antagonist [Sar',Thr 8 ]angiotensin II into the nucleus tractus solitarii. Assessment of angiotensin II binding sites in the solitary-vagal complex 24 hours after denervation showed a 13% reduction in angiotensin receptors. These findings confirm that both angiotensin II and angiotensin-(1-7) express biological activity through receptor-mediated actions in the dorsal medulla oblongata. That the effects produced by angiotensin II do not require the integrity of baroreceptor input further suggests that the receptors responsible for the acute cardiovascular actions of this peptide reside on postsynaptic elements in the vagal-solitary complex. {Hypertension 1990;15(suppl I):I-34-I-39)

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“…Dense immunostaining for Ang-(1-7) immunoreactivity has been demonstrated in the supraoptic and paraventricular nuclei of the hypothalamus and neurohypophysical (11), and Ang-(1-7) is as potent as Ang II in releasing AVP from hypothalamus-neurohypophysial explants (12). In addition, we have shown that Ang-(1-7) possesses a potent peripheral antidiuretic activity in water-loaded rats that is not influenced by blockade of vasopressin V 2 receptors (13,14).…”

Section: Introductionmentioning

confidence: 99%

Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats

Baracho

Silva

Khosla

et al. 1998

Braz J Med Biol Res

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In the present study we evaluated the nature of angiotensin receptors involved in the antidiuretic effect of angiotensin-(1-7) (Ang-(1-7)) in water-loaded rats. Water diuresis was induced in male Wistar rats weighing 280 to 320 g by water load (5 ml/100 g body weight by gavage). Immediately after water load the rats were treated subcutaneously with (doses are per 100 g body weight): 1) vehicle (0.05 ml 0.9%

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Immunocytochemical localization of angiotensin-(1–7) in the rat forebrain

Cited by 83 publications

References 22 publications

Renal actions of angiotensin-(1-7)

Renal actions of angiotensin-(1-7)

Actions of angiotensin peptides after partial denervation of the solitary tract nucleus.

Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats

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