Immunocytochemical localization of peptides and other neurochemicals in the rat laterodorsal tegmental nucleus and adjacent area

Sutin, Ellen L.; Jacobowitz, David M.

doi:10.1002/cne.902700206

Cited by 152 publications

(62 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study was able to confirm all of these localizations with in situ hybridization histochemistry except the pedunculopontine tegmental nucleus, the accessory trigeminal nucleus, and the ventral nucleus of the trapezoid body. Several of these localizations have also been described in immunocytochemical (McGinty, 1985;Sutin and Jacobowitz, 1988;Moga et al, 1990;Van Bockstaele et al, 1995) and/or in situ hybridization histochemical (Young et al, 1986;Alvarez-Bolado et al, 1990) studies of restricted regions of the rat brain.…”

Section: Distribution Of the Expression Of The Preprodynorphin Genementioning

confidence: 90%

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

et al. 1997

View full text Add to dashboard Cite

The distribution of preprodynorphin messenger RNA-containing perikarya in the central nervous system of the rat was determined with in situ hybridization histochemistry using a 35S-labelled complementary RNA probe. All of the regions of the central nervous system reported by other investigators to contain perikarya that synthesize prodynorphin-derived peptides, except the pedunculopontine tegmental nucleus, the accessory trigeminal nucleus, and the ventral nucleus of the trapezoid body, also contained perikarya that synthesize preprodynorphin messenger RNA. However, the olfactory bulb, the anterior olfactory nucleus, the islands of Calleja, the CA1-CA3 fields of the hippocampus, the septohippocampal nucleus, the diagonal band of Broca, the basal and cortical amygdaloid nuclei, the entopeduncular nucleus, the subthalamic nucleus, the superior colliculus, the Edinger-Westphal nucleus, the dentate nucleus, the raphes linearis and pontis, the dorsal cochlear nucleus, the medial vestibular nucleus, the inferior olive, and the dorsal motor nucleus of the vagus nerve also contained preprodynorphin messenger RNA-synthesizing perikarya. These observations suggest that prodynorphin-derived peptides have a much more pervasive role in central nervous system function than previously suspected. However, before the physiological significance of these observations can be judged, it will be necessary to determine whether all of the novel sites of preprodynorphin messenger RNA synthesis are sites of prohormone synthesis and conventional processing.

show abstract

Section: Distribution Of the Expression Of The Preprodynorphin Genementioning

confidence: 90%

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

et al. 1997

View full text Add to dashboard Cite

show abstract

“…Peoples et al (2002) examined the ultrastructural associations of endomorphin-1 with the NA neurons of the LC and the peptidergic neurons of Barrington's nucleus in the brainstem dorsal pontine tegmentum. Both structures, targeted by endogenous opioids (Sutin and Jacobowitz, 1988;Van Bockstaele et al, 1996c) and enriched with -opioid receptors (Atweh and Kuhar, 1977;Van Bockstaele et al, 1996a,b), might be involved in the reduction of the excitability of the LC neurons caused by endomorphins (Peoples et al, 2002). It was demonstrated that endomorphin-1-immunoreactive axon terminals form synaptic specializations with tyrosine hydroxylase-and CRF-containing dendrites in peri-LC and Barrington's nucleus, respectively, in the dorsal pontine tegmentum of the rat brain.…”

Section: Modulation Of Noradrenaline Transmissionmentioning

confidence: 99%

The Endomorphin System and Its Evolving Neurophysiological Role

Fichna

Janecka²,

Costentin³

et al. 2007

Pharmacol Rev

222

171

View full text Add to dashboard Cite

“…Van den Bergh et al (1988) described the distribution of TRH, enkephalin, somatostatin, substance P, neurotensin, and peptide isoleucine histidine (PHI) cell bodies. Sutin and Jacobowitz (1988) analyzed neuropeptides in the most caudal part of the vPAG reporting on neurotensin, galanin, VIP, CCK, substance P, calcitonin gene-related peptide (CGRP), somatostatin, and atrial natriuretic factor. Smith et al (1994) compared the distribution of the transcripts for enkephalin, substance P, somatostatin, galanin, VIP, NPY, and CGRP at three different levels of the PAG.…”

mentioning

confidence: 99%

Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain

Maître

Fabre

et al. 2010

J of Comparative Neurology

162

141

View full text Add to dashboard Cite

Serotonin neurons play a major role in many normal and pathological brain functions. In the rat these neurons have a varying number of cotransmitters, including neuropeptides. Here we studied, with histochemical techniques, the relation between serotonin, some other small-molecule transmitters, and a number of neuropeptides in the dorsal raphe nucleus (DRN) and the adjacent ventral periaqueductal gray (vPAG) of mouse, an important question being to establish possible differences from rat. Even if similarly distributed, the serotonin neurons in mouse lacked the extensive coexpression of nitric oxide synthase and galanin seen in rat. Although partly overlapping in the vPAG, no evidence was obtained for the coexistence of serotonin with dopamine, substance P, cholecystokinin, enkephalin, somatostatin, neurotensin, dynorphin, thyrotropin-releasing hormone, or corticotropin-releasing hormone. However, some serotonin neurons expressed the gamma-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD). Work in other laboratories suggests that, as in rat, serotonin neurons in the mouse midline DRN express the vesicular glutamate transporter 3, presumably releasing glutamate. Our study also shows that many of the neuropeptides studied (substance P, galanin, neurotensin, dynorphin, and corticotropin-releasing factor) are present in nerve terminal networks of varying densities close to the serotonin neurons, and therefore may directly or indirectly influence these cells. The apparently low numbers of coexisting messengers in mouse serotonin neurons, compared to rat, indicate considerable species differences with regard to the chemical neuronatomy of the DRN. Thus, extrapolation of DRN physiology, and possibly pathology, from rat to mouse, and even human, should be made with caution.

show abstract

Immunocytochemical localization of peptides and other neurochemicals in the rat laterodorsal tegmental nucleus and adjacent area

Cited by 152 publications

References 73 publications

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

The Endomorphin System and Its Evolving Neurophysiological Role

Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures of the mouse brain

Contact Info

Product

Resources

About