“…We are investigating factors controlling the adhesion of small cell lung carcinoma (SCLC) cells. SCLC cells express NCAM (Kibbelaar et al, 1989;Patel et al, 1989;Aletsee-Ufrecht et al, 1990;Rygaard et al, 1992), ICAM-1 (Boyd et al, 1989), carcinoembryonic antigen (CEA) (Goslin et al, 1983;Bepler et al, 1989), and members of the integrin (Hemler et al, 1990;Feldman et al, 1991) and cadherin (Shimoyama et al, 1989;Rygaard et al, 1992) gene families. SCLC cells also express receptors for neurotransmitters (Sorenson et al, 1983;Cunningham et al, 1985;Maneckjee and Minna, 1990;Williams and Lennon, 1990) and autocrine growth factors (for review see Weynants et al, 1990), and it is possible that activation of these receptors may modulate the expression or activity of SCLC adhesion molecules.…”