Immunocytochemistry for SOX‐11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies

Foo, Wen‐Chi; Harrison, Grant; Zhang, Xuefeng

doi:10.1002/cncy.21931

Cited by 25 publications

(37 citation statements)

References 22 publications

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Section: Introductionmentioning

confidence: 99%

“…Recently, after extensive molecular characterization of SPNs, multiple authors have identified additional IHC stains that are useful in the identification of SPNs . These IHC stains include lymphoid enhancer‐binding factor 1 (LEF1) and androgen receptor (AR), in addition to transcription factor binding to IGHM enhancer 3 ( TFE3 ) and SRY‐box 11 (SOX11) . Although the surgical pathology literature has reported that strong and diffuse nuclear positivity for LEF1 and AR is frequent in SPN surgical resection specimens (frequency of 93.4% and 81.5%, respectively), to our knowledge no study to date has evaluated the usefulness of these markers on cytology specimens.…”

Section: Introductionmentioning

confidence: 99%

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The usefulness of lymphoid enhancer‐binding factor 1 and androgen receptor in diagnosing solid pseudopapillary neoplasm of the pancreas on cytopathology

McHugh

Stelow

Harrison

et al. 2019

Cancer Cytopathology

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BACKGROUND: Solid pseudopapillary neoplasm (SPN) is an uncommon tumor that is challenging to diagnose on cytology due to morphologic overlap with other pancreatic neoplasms. Recently, putative diagnostic markers for SPN have been reported in the surgical pathology literature, with nuclear positivity for lymphoid enhancer-binding factor 1 (LEF1) and androgen receptor (AR) identified in >90% and >80% of cases, respectively. In the current study, the authors sought to evaluate the sensitivity and specificity of LEF1 and AR on SPN cytology specimens and available corresponding surgical resection specimens. METHODS: Immunohistochemistry was performed using monoclonal antibodies against LEF1 and AR on 19 SPN cytology cases and 15 corresponding follow-up surgical resection specimens from 2 institutions. To evaluate specificity, the authors stained 23 non-SPN tumors diagnosed on cytology with corresponding surgical specimens (4 acinar cell carcinomas, 9 pancreatic neuroendocrine tumors, and 10 ductal adenocarcinomas). Positivity for LEF1 and AR was defined as any nuclear staining within neoplastic nuclei. RESULTS: LEF1 was found to be positive in 18 of 19 cytology cases (94.7%) and 15 of 15 corresponding surgical resection specimens (100%). AR was positive in 4 of 16 cytology cases (25.0%) and 4 of 15 corresponding surgical resection specimens (26.7%). Among non-SPN tumors, LEF1 demonstrated a specificity of 87% whereas the specificity for AR was 100%. CONCLUSIONS: LEF1 for SPN on cytology material was found to demonstrate a sensitivity of 94.7% and a specificity of 87%. Although AR was found to have a specificity of 100%, its sensitivity was lower (25%). LEF1 could be a valuable immunostain on cytology cell block material for the diagnosis of SPN. However, the same may not hold true for AR.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The usefulness of lymphoid enhancer‐binding factor 1 and androgen receptor in diagnosing solid pseudopapillary neoplasm of the pancreas on cytopathology

McHugh

Stelow

Harrison

et al. 2019

Cancer Cytopathology

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show abstract

“…Although the aspecific NSE is usually positive, but the chromogranin-A or synaptophysin are negative, moreover, no hormonal activity is identified in this tumor. The nuclear expression of βcatenin, SOX-11 and TFE3 positivities are characteristic findings in SPN [71], but not in PNET and in acinar cell carcinoma (Fig. 2i).…”

Section: Important Practical Pathological Considerationsmentioning

confidence: 92%

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

Zalatnai

Kis-Orha

2019

Pathol. Oncol. Res.

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The solid-pseudopapillary neoplasm of the pancreas is a rare but enigmatic entity occurring mainly in young women. Since the first description by V. Frantz in 1959 the terminology of this tumor has continuously changed but it has remained simply descriptive, because the exact histogenesis is still obscure. Although in majority of cases the survival is excellent, nevertheless, the expected prognosis is not exactly predictable. In this review the authors aim to summarize its clinico-pathological features, the expected biological behavior, the molecular alterations, the immune phenotype and discuss the putative histogenesis. From diagnostic point of view, the salient histological characteristic findings are analyzed that would help to differentiate it from other, look-alike pancreatic tumors, and suggestions are made about the desirable content of the histological report.

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“…In case of diagnostic uncertainty, EUSguided fine needle aspiration is recommended, which plays an important role in providing accurate and reliable preoperative cytological diagnosis (61,62,63). Papavramidis and Papavramidis (49) include CT-guided FNA in the SPN diagnostic algorithm.…”

Section: Magnetic Resonance Imaging (Mri) Is the Diagnostic Methods Ofmentioning

confidence: 99%

Pancreatic Cystic Neoplasms: Diagnosis, Management and Indications for Surgical Procedures. Part II

Bauer¹

2018

chr

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Immunocytochemistry for SOX‐11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies

Abstract: SOX-11 is a sensitive and specific immunocytochemical stain for SPNs in EUS-FNA specimens, and it may be useful as a diagnostic marker for distinguishing SPNs from its cytologic mimics. Cancer Cytopathol 2017;125:831-7. © 2017 American Cancer Society.

Cited by 25 publications

References 22 publications

The usefulness of lymphoid enhancer‐binding factor 1 and androgen receptor in diagnosing solid pseudopapillary neoplasm of the pancreas on cytopathology

The usefulness of lymphoid enhancer‐binding factor 1 and androgen receptor in diagnosing solid pseudopapillary neoplasm of the pancreas on cytopathology

Solid-pseudopapillary Neoplasms of the Pancreas is still an Enigma: a Clinicopathological Review

Pancreatic Cystic Neoplasms: Diagnosis, Management and Indications for Surgical Procedures. Part II

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