Immunocytochemistry on Scrape Cytology in Breast Cancer

Low concordance of biomarkers in histopathological and cytological material from breast cancer

“…Using ICC on FNA for evaluation of biomarkers used in routine clinical practice, resulted in classifications of ER and PR status that differed significantly from the evaluations made by IHC (ER κ = 0.62–0.63, PR κ = 0.82). Several authors have reported similar results previously, and Radhika et al . have shown a congruence of positive and negative cases as low as 50% for ER and 29% for PR …”

Estrogen and progesterone hormone receptor status in breast carcinoma: Comparison of immunocytochemistry and immunohistochemistry

“…The concordance between cytology and histology was 84% for ER and 90% for PR in the study by Malaviya et al [6] Both the positivity rates and the staining intensity scores were higher for cytochemistry than for histochemistry.…”

Multinational study of oestrogen and progesterone receptor immunocytochemistry on breast carcinoma fine needle aspirates

“…Several types of cytological preparations have already been used successfully for the determination of hormonal receptors by ICC including smears, imprints, cytospins and monolayer preparations. Smears have been used in the majority of reports, mainly obtained by FNA 3–13 or by scraping surgical biopsies 14,15 . Schmitt et al.…”