Immunocytotoxicity, cytogenotoxicity and genotoxicity of cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis

Rocha, Thiago Lopes; Gomes, Tânia; Cardoso, Cátia; Letendre, Julie; Pinheiro, José Paulo; Sousa, Vânia Serrão; Bebianno, Maria João

doi:10.1016/j.marenvres.2014.07.009

Cited by 83 publications

(60 citation statements)

References 39 publications

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“…Other similar studies by King-Heiden et al (2009) showed low accumulation values of Cd in zebrafish larvae exposed to 0.2-20 µM Cd-eq of QDs following 120-hour exposure. In addition, some authors suggested lower accumulation of QDs in fish than Cd accumulation from its salt, indicating a higher bioavailability of QDs over time (Rocha et al 2014;Zarco-Fernández et al 2016). It is in good agreement with our findings that the BCF values of Cd in early stages of development of fish exposed to QDs reached the maximum at the end of both tests.…”

Section: Bioconcentration Factor (Bcf)supporting

confidence: 93%

Accumulation of Cd in the Early Stages of the Development of Rainbow Trout Oncorhynchus mykiss Exposed to Cd-Based Quantum Dots and Cd Salt

Cibulskaitė

Kazlauskienė

Jokšas

et al. 2017

Proccedings of 10th International Conference "Environmental Engineering"

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Abstract. The main aims of the present study were: 1) to determine the concentration of Cd in water during the experiment after long-term exposure to rainbow trout embryos and larvae to sublethal concentrations of Cd-based quantum dots (QDs) and Cd chloride salt, and 2) to evaluate accumulation of Cd in the whole body of test-organisms depending on the type of chemical substances (QDs or single Cd) and the duration of exposure. Experimental studies at the early developmental stages of rainbow trout were performed under static conditions. Cd concentration in water during the experiment was significantly higher in QD solution than in CdCl2 solution, and it declined over time. A comparative analysis indicated that the Cd accumulation in testorganisms from QDs was mostly higher than that from CdCl2. The accumulation of Cd from QDs tends to increase with increasing duration of exposure. The bioconcentration factor for Cd increased in embryos and larvae over time until reaching the maximum at the end of the QD exposition.

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Section: Bioconcentration Factor (Bcf)supporting

confidence: 93%

Accumulation of Cd in the Early Stages of the Development of Rainbow Trout Oncorhynchus mykiss Exposed to Cd-Based Quantum Dots and Cd Salt

Cibulskaitė

Kazlauskienė

Jokšas

et al. 2017

Proccedings of 10th International Conference "Environmental Engineering"

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“…in several studies using in vitro and in vivo exposure (Gagné et al, 2008a;Peyrot et al, 2009;Katsumiti et al, 2014;Rocha et al, 2014;2015a;Buffet et al, 2015). However, the mechanisms of QD-mediated toxicity are not well established and depend on size, chemical composition, surface coating and exposure conditions.…”

Section: Ecotoxicological Impact Of Cd-based Qds In Aquatic Organismsmentioning

confidence: 99%

“…From the context of aquatic nanotoxicology, bivalve species have the higher capacity to concentrate Cd-based QDs from water than other animals, which can induce severe tissue and cellular damage (Gagné et al, 2008a;Peyrot et al, 2009;Rocha et al, 2014;2015a;Buffet et al, 2015). In vitro toxicity of CdS QDs (5 nm; 10 -4 -10 2 mgCd.L -1 ; 24 h) in Mytilus galloprovincialis hemocytes and gill cells was associated with extraand intracellular release of Cd 2+ ions and consequent oxidative damage (Katsumiti et al, 2014).…”

Section: Ecotoxicological Impact Of Cd-based Qds In Aquatic Organismsmentioning

confidence: 99%

“…The increasing production and use of these engineered nanoparticles (ENPs) will likely increase their release into the aquatic environment. Although QDs concentrations in the environment are unavailable, there are increasing concerns about their possible ecological risks and toxicity to human health (Hardman, 2006;Rocha et al, 2014Rocha et al, , 2015a.…”

Section: Introductionmentioning

confidence: 99%

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Tissue specific responses to cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis

et al. 2015

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“…LPO can interfere with membrane structure and function by changing membrane fluidity, breaking the membrane integrity, passivating membrane-bound enzymes and disrupting surface receptor molecules [81]. Many other contaminants, including tributyltinoxide and cadmium, can induce alterations in cell membranes and cause destabilization and reduce cell viability [5,26,52,67]. Additionally, lipid hydroperoxides form at the early stages of LPO, these can take part in redox reactions and exacerbate peroxidative cell injury [25].…”

Section: Antioxidant Responses Of P Martensii To Pyrenementioning

confidence: 99%

Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii

Xie

Zhao

Han

et al. 2017

Fish & Shellfish Immunology

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a b s t r a c tPyrene is a polycyclic aromatic hydrocarbon (PAH) commonly observed in aquatic ecosystems, which originates primarily from the incomplete combustion of fossil fuels and the use of petroleum compounds. Pyrene can cause the immune disturbance and oxidative stress, result in immunotoxicity, DNA damage, reduce reproduction significantly, and induce behavioral changes. Marine bivalves are commonly used as bioindicators for marine pollution, and hemolymph is a metabolite transfer medium for PAH pollutant. However, the vital immune indicator responses of pearl oyster Pinctada martensii hemolymph exposed to pyrene is still unclear. Thus, the immunotoxic responses of pyrene on the hemolymph of the Pinctada martensii were investigated in this study. After exposure to pyrene for 7 days, the total number of hemocytes (THC), cell membrane stability (CMS), phagocytic activity (PA) and total glutathione (GSH T ) all decreased significantly. Pyrene also caused a significant increase in lipid peroxi- ) and GSH T (7.2 mg L À1 ), which indicates that THC and LPO were more sensitive. Additionally, a clear dose-effect relationship indicated that pyrene stimulated a marked immune response, as well as oxidative stress in P. martensii, which demonstrates the subtle effects of pyrene exposure on marine invertebrates and the potential associated risk.

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Immunocytotoxicity, cytogenotoxicity and genotoxicity of cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis

Cited by 83 publications

References 39 publications

Accumulation of Cd in the Early Stages of the Development of Rainbow Trout Oncorhynchus mykiss Exposed to Cd-Based Quantum Dots and Cd Salt

Accumulation of Cd in the Early Stages of the Development of Rainbow Trout Oncorhynchus mykiss Exposed to Cd-Based Quantum Dots and Cd Salt

Tissue specific responses to cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis

Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii

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