Immunoelectronmicroscopic differentiation of linear IgA bullous dermatosis of adults with coexistence of IgA and IgG deposition from bullous pemphigoid

Adachi, Atsuko; Tani, Masahiro; Matsubayashi, Shuho; Shibata, Koichi; Horikawa, Tsuyoshi; Murata, Yozo; Kumano, Kimiko

doi:10.1016/0190-9622(92)70205-t

Cited by 20 publications

(9 citation statements)

References 19 publications

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“…Hence, the diagnosis in the latter case was established based on the clinical characteristics, the lack of symptoms from the intestines, and a negative screening for coeliac disease. Mixed deposits are previously described in a number of cases (11)(12)(13)(14)(15)(16)(17)(18). Their significance remains uncertain but it may be confusing and make the differential diagnosis more difficult.…”

Section: Discussionmentioning

confidence: 94%

Linear IgA Bullous Dermatosis: A Retrospective Study of 23 Patients in Denmark

Lings¹,

Bygum

2015

Acta Derm Venerol

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Linear IgA bullous dermatosis (LAD) is an autoimmune, chronic bullous disease affecting primarily young children and adults. Studies on LAD are relatively sparse and from Scandinavia we could only find a few case reports. Therefore we decided to conduct a retrospective investigation of patients seen at our department since 1972. A total of 23 patients were identified; 7 children (F:M ratio 0.75) and 16 adults (F:M ratio 0.78). Mean age at disease onset in the two age groups were 2.7 and 56.8 years. Estimated incidence rate in our region: 0.67 per million per year. The most commonly used treatment modalities were corticosteroids, dapsone and sulphapyridine.

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Section: Discussionmentioning

confidence: 94%

Linear IgA Bullous Dermatosis: A Retrospective Study of 23 Patients in Denmark

Lings¹,

Bygum

2015

Acta Derm Venerol

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“…The past immuno-electron microscopy studies demon strated 2 ultrastructural sites of deposition of IgA BMZ antibody, the lamina lucida, below the lamina densa and a combination of both sites [18][19][20][21][22][23][24][25][26][27][28][29], Heterogeneity of the localization of the target antigens was demonstrated using skin split through the lamina lucida for the detection of the circulating BMZ antibodies. The majority of sera bound to the epidermis and a minority to the dermis with salt-split skin.…”

Section: Discussionmentioning

confidence: 99%

Linear IgA Disease: A Heterogeneous Disease

1994

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Data from our series of 70 patients support the hypothesis that linear IgA disease is a heterogeneous disease as regards clinical features, target antigens and immunogenetics. The clinical presentation varies as regards age of onset and severity of skin and mucosal involvement and scarring. The use of split skin and of the novel substrate cylindroma has identified 2 target antigens. The majority of patients have a target antigen associated with epidermal cells and possibly cylindroma hemidesmosomes. A minority have a dermal antigen which resembles collagen VII on cylindroma. There is an association with HLA-B8, -DR3, -Cw7 and with the linked rare tumour necrosis factor a allele, but this is not universal. These differences do not correlate with each other.

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“…Hall & Lawley (17), in a study of IgA subclasses in dermatitis herpetiformis patients found that in 11 patients with``DH-linear'' now known to be LABD, IgA1 deposition was found in 10 patients and IgA2 deposition in 1 patient. Adachi et al (18) found IgA2 deposition in a patient who had sub-lamina densa deposition of antibody by immunoelectron microscopy. Onodera et al (19), described a patient with IgA1 and IgA2 BMZ antibodies on DIF with only the presence of circulating IgA1 antibodies.…”

Section: Discussionmentioning

confidence: 99%

IgA Antibodies Recognizing LABD97 Are Predominantly IgA1 Subclass

Egan

Martineau

Taylor

et al. 1999

Acta Dermato-Venereologica

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Linear IgA bullous dermatosis is a rare acquired subepidermal blistering disease of the skin. A recognized antigen in linear IgA bullous dermatosis is a 97-kDa basement membrane zone protein termed LABD97. Previous studies, using immunofluorescent techniques, have suggested that the IgA response is restricted to the IgA1 subclass. We studied the IgA antibody subclasses in the sera of 6 patients that contained circulating IgA antibodies reactive with LABD97. The methods used included direct and indirect immunofluorescence and Western immunoblot. All patients tested had IgA1 anti-LABD97 antibodies detected by all 3 methods. Two patients had IgA2 antibodies detected by direct immunofluorescence. Three patients had IgA2 antibodies on indirect immunofluorescence. Two of these also had anti-LABD97 IgA2 antibodies and 1 had secretory component containing anti-LABD IgA antibodies on Western immunoblot. We conclude that the predominant IgA antibody subclass reactive with LABD97 in LABD is IgA1, although the IgA2 subclass may be involved in some cases.

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Immunoelectronmicroscopic differentiation of linear IgA bullous dermatosis of adults with coexistence of IgA and IgG deposition from bullous pemphigoid

Cited by 20 publications

References 19 publications

Linear IgA Bullous Dermatosis: A Retrospective Study of 23 Patients in Denmark

Linear IgA Bullous Dermatosis: A Retrospective Study of 23 Patients in Denmark

Linear IgA Disease: A Heterogeneous Disease

IgA Antibodies Recognizing LABD97 Are Predominantly IgA1 Subclass

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