Immunoexpression of Interleukin 17, Transforming Growth Factor β1, and Forkhead Box P3 in Periapical Granulomas, Radicular Cysts, and Residual Radicular Cysts

Andrade, Ana Luiza Dias Leite de; Nonaka, Cassiano Francisco Weege; Gordón-Núñez, Manuel Antônio; Freitas, Roseana de Almeida; Galvão, Hébel Cavalcanti

doi:10.1016/j.joen.2013.04.028

Cited by 39 publications

(70 citation statements)

References 35 publications

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“…Lesions were analyzed based on histological and radiographic characteristics to differentiate between periapical granulomas, 14,15,16,17,18,21 periapical cysts 14,21 and residual radicular cysts. 16,17,18 Two articles classified lesions only as periapical, without differentiatinge into granuloma or periapical cysts. 19,20 A statistically significant association was found between Treg/Th17 markers and clinicopathological features of chronic inflammatory periapical lesions in human tissues.…”

Section: Results Of Individual Studiesmentioning

confidence: 99%

“…In phase 2, the full-text of 18 studies were retrieved and evaluated. Of those, only eight 14,15,16,17,18,19,20,21 met the eligibility criteria. No additional study was identified in the reference lists of the included articles and in the grey literature.…”

Section: Study Selectionmentioning

confidence: 99%

“…Samples of six articles 14,15,18,19,20,21 were obtained directly through surgery and samples of the other two studies were obtained through institutional archives collected from previous surgical procedures. 16,17 Fou r a r t icles repor ted t he mea n age of participants 18,19,20,21 and five studies defined the range between 17 and 64 years. 14,15,19,20,21 The language of the articles was predominantly English, although the studies were conducted in different countries (Brazil, United States and Serbia).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…18,20 Real-time polymerase chain reaction (RT-PCR) was used in three studies, 14,15,21 flow cytometry in two studies, 19,20 confocal microscopy in one study, 19 and immunohistochemistry was used in four studies. 16,17,18,20 The entire description of studies characteristics is shown in Table 2.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The cross-sectional studies 16,17,19,20 were rated between two and three. The case-controls studies 14,15,18,21 between six and nine.…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

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Treg and Th17 cells in inflammatory periapical disease: a systematic review

et al. 2017

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The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.

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Section: Results Of Individual Studiesmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…The cross-sectional studies 16,17,19,20 were rated between two and three. The case-controls studies 14,15,18,21 between six and nine.…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

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Treg and Th17 cells in inflammatory periapical disease: a systematic review

et al. 2017

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Cytokine Networks Regulating Inflammation and Immune Defense in the Oral Cavity

Cavalla

Araujo-Pires

Biguetti

et al. 2014

Curr Oral Health Rep

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The host/pathogen interaction in infectious oral diseases is characterized by complex and precisely orchestrated host response mechanisms aimed to protect the host against the microbial challenge with minimal collateral damage to host cells and tissues. Central to the host response in this battlefront is the expression of cytokines. The resulting cytokine networks, which ultimately regulate the host response at multiple levels, thereby determine the clinical outcome of the disease and explain most of its defining features from a mechanistic viewpoint. This review intends to present a structured view of the intricate cytokine networks that regulate inflammation and immune defense in the oral cavity, guiding the reader throughout the evolving paradigms that describe how the simultaneous action of multiple cytokines shapes the nature of the immune response to oral infection.

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LPS-miR-34a-CCL22 axis contributes to regulatory T cell recruitment in periapical lesions

He¹,

Song

et al. 2015

Biochemical and Biophysical Research Communications

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Immunoexpression of Interleukin 17, Transforming Growth Factor β1, and Forkhead Box P3 in Periapical Granulomas, Radicular Cysts, and Residual Radicular Cysts

Cited by 39 publications

References 35 publications

Treg and Th17 cells in inflammatory periapical disease: a systematic review

Treg and Th17 cells in inflammatory periapical disease: a systematic review

Cytokine Networks Regulating Inflammation and Immune Defense in the Oral Cavity

LPS-miR-34a-CCL22 axis contributes to regulatory T cell recruitment in periapical lesions

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