Immunofluorescence Microscopic Studies of Recurrent Aphthous Stomatitis

VanHale, Harriet M.

doi:10.1001/archderm.1981.01650120025014

Cited by 19 publications

(7 citation statements)

References 11 publications

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“…Studying a population similar to ours, comprising 22 patients, VanHale et al 18 did not find IgA on vessel walls, nor in the basal membrane zone. IgG was also negative on vessel walls.…”

Section: Discussionsupporting

confidence: 63%

“…The main physiopathological hypothesis for the origin of RAS lesions are associated with humoral or cellular immunity 4,[15][16][17][18][19][20] . Most of the studies aforementioned, among other exams, used direct immunofluorescence (DIf) in order to try to prove the presence or absence of immunocomplex deposits on the mucosa of patients with RAS.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, other authors [16][17][18] found IgG and C3, during DIf, and they advocate that humoral response is present in RAS genesis.…”

Section: Introductionmentioning

confidence: 95%

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O papel da imunofluorescência direta na fisiopatologia e no diagnóstico diferencial da estomatite aftóide recorrente

Wilhelmsen

Weber

Miziara

2008

Rev. Bras. Otorrinolaringol.

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Recurrent aphthous stomatitis (RAS) is a diseasecharacterized by the periodic appearance of aphthous lesions on the oral mucosa, of which etiology and physiopathology are not well explained. Recent studies with direct immunofluorescence show controversial results. Some reveal that the basic disorder is associated with humoral immunity, while others point to changes in cellular immunity. Atypical forms of aphthous stomatitis may have its differential diagnosis carried out with vesicobullous diseases, such as pemphigus vulgaris. Aim: Check the presence of immunocomplexes in the mucosa of patients with aphthous stomatitis and the usefulness of the differential diagnosis method with bullous skin diseases. Materials and methods: 23 patients with aphthous stomatitis were prospectively included in the study. There were all submitted to mucosa biopsy under local anesthesia for the removal of two fragments. One of these was sent to histology and, the other to direct immunofluorescence. Results: The 23 samples from the histology exam revealed an ulcerated inflammatory process. The samples referred to immunofluorescence resulted negative and only one showed the presence of complement in the basal membrane. Conclusion: Based on our results, we conclude that the patients with RAS do not show deposits of immunocomplexes in their oral cavity mucosa and immunofluorescence is useful in the differential diagnosis between this disease and bullous skin diseases.

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“…Studying a population similar to ours, comprising 22 patients, VanHale et al 18 did not find IgA on vessel walls, nor in the basal membrane zone. IgG was also negative on vessel walls.…”

Section: Discussionsupporting

confidence: 63%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

O papel da imunofluorescência direta na fisiopatologia e no diagnóstico diferencial da estomatite aftóide recorrente

Wilhelmsen

Weber

Miziara

2008

Rev. Bras. Otorrinolaringol.

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“…Genel olarak hastalar hastalığın sadece bir klinik tipine sahiptirler. Yine de iki ayrı klinik tipin aynı anda bulunabildiği bildirilmiştir 20 . Hastalarımızın 88'inde (%88) MiRAS saptanması, en sık görülen RAS tipinin MiRAS olduğu şeklindeki mevcut literatürü desteklemektedir.…”

Section: Discussionunclassified

Sociodemographic and clinical characteristics of patients with recurrent aphthous stomatitis

Bahalı¹,

Köktürk²,

Güvenç³

2014

TURKDERM

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Background and Design:The purpose of this study was to obtain data that may provide an insight into the etiopathogenesis of recurrent aphtous stomatitis (RAS) by the way of analysing the sociodemographic and clinical characteristics of patients who had been diagnosed with RAS. Materials and Metods: The patients, who were diagnosed with RAS in the dermatology outpatient clinic, between May 2007 and May 2010, were evaluated retrospectively. The data including sociodemografic and clinical characteristics, and treatment options were recorded. Results: A hundred patients (68 women, 32 men) were included in this study. The average age was 40±13.6 years. RAS was more common in patients with middle-income and low education. The most common type of RAS was minor aphtous ulcers (88%). The lesions were most frequently seen on the lateral side of the tongue (34%) and cheek (34%). Sixty percent of patients had a positive family history. Some factors such as biting (12%), tooth brushing (18%), dental disease presence (82%), food (39%), menstruation (10.3%), stress (76%), iron deficiency (16.7%), vitamin B12 deficiency (22.4%), low serum ferritin levels (18%), and seasonal variability (32%) showed positive correlation with RAS. A negative correlation was found between RAS and smoking. Forty-nine percent of patients had used alternative therapies in addition to drug therapy. The most frequently used alternative method was consumption of sumac (26.5%). Conlucions: In contrast to the literature, our study found that RAS is started in the third decade of life and, approximately 50% of patients prefered alternative treatment methods, particularly sumac. Nowadays, discussions about the etiopathogenesis of RAS continue. In this study, we found that different sociodemographic and clinical factors may be associated with the etiopathogenesis of the disease. Our study will be followed by further studies using prospective design to identify the the etiopathogenesis of RAS. (Turkderm 2014; 48: 242-8)

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“…Embora autores tenham encontrado depósitos de C 3 , IgM e IgA em pacientes com EAR (Donatsky e Dabelsteen, 1977;Ullman e Gorlin, 1978;VanHale et al, 1981;Reimer et al, 1983), nosso estudo não evidenciou o mesmo resultado.…”

Section: -Imunofluorescência Direta E Earunclassified

Estudo preliminar da correlação entre antígenos de histocompatibilidade (HLA) e estomatite aftóide recorrente em população brasileira

Wilhelmsen¹

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Immunofluorescence Microscopic Studies of Recurrent Aphthous Stomatitis

Cited by 19 publications

References 11 publications

O papel da imunofluorescência direta na fisiopatologia e no diagnóstico diferencial da estomatite aftóide recorrente

O papel da imunofluorescência direta na fisiopatologia e no diagnóstico diferencial da estomatite aftóide recorrente

Sociodemographic and clinical characteristics of patients with recurrent aphthous stomatitis

Estudo preliminar da correlação entre antígenos de histocompatibilidade (HLA) e estomatite aftóide recorrente em população brasileira

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